Mohammad Hammoud
University of Bordeaux
5 Papers
75 Citations
Mohammad Hammoud is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Haematopoiesis & Endothelial stem cell. The author has an hindex of 3, co-authored 3 publications. Previous affiliations of Mohammad Hammoud include University of Franche-Comté.
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Papers
Slow-cycling/quiescence balance of hematopoietic stem cells is related to physiological gradient of oxygen.
TL;DR: It is suggested that a very low O(2) concentration is necessary but not sufficient to induce hematopoietic stem cell quiescence and it is proposed to use in situ normoxia instead of the confusing term hypoxia when working with normal cells at physiological low O (2) concentrations.
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Combination of low O2 concentration and mesenchymal stromal cells during culture of cord blood CD34+ cells improves the maintenance and proliferative capacity of hematopoietic stem cells
Mohammad Hammoud,Mohammad Hammoud,Marija Vlaski,Pascale Duchez,Jean Chevaleyre,Xavier Lafarge,Jean-Michel Boiron,Vincent Praloran,Philippe Brunet de la Grange,Zoran Ivanovic +9 more
TL;DR: The data demonstrate that association of co‐culture and low O2 concentration not only induces sufficient expansion of committed progenitors (with respect to the classical culture), but also ensures a better maintenance/expansion of hematopoietic stem cells (HSCs), pointing to the oxygenation as a physiological regulatory factor but also as a cell engineering tool.
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Low O 2 concentrations enhance the positive effect of IL-17 on the maintenance of erythroid progenitors during co-culture of CD34+ and mesenchymal stem cells
Aleksandra Krstić,Marija Vlaski,Mohammad Hammoud,Jean Chevaleyre,Pascale Duchez,Gordana Jovčić,Diana Bugarski,Pavle Milenković,Philippe Bourin,Jean-Michel Boiron,Vincent Praloran,Zoran Ivanovic +11 more
TL;DR: It is demonstrated that IL-17 enhances CD34+ and total CFC production during the five days of MSC/CD34+ co-culture, strengthening the concept that physiological levels of O2, should be considered as an important environmental factor that significantly influences cytokine activity.
19
Anti-SARS-CoV-2 antibody response after 2 and 3 doses of BNT162b2 mRNA vaccine in patients with lymphoid malignancies
Simon B. Gressens,Slim Fourati,Anne Le Bouter,Fabien Le Bras,Jehan Dupuis,Mohammad Hammoud,T. El Gnaoui,Romain Gounot,L. Roulin,Karim Belhadj,Corinne Haioun,Sebastien Gallien,Giovanna Melica,François A. Lemonnier +13 more
TL;DR: In this paper , a single-centre study, evaluating the serological responses of mRNA vaccination amongst a cohort of 200 patients affected by lymphoid malignancies after two or three doses using an industrial SARS-CoV-2 serology assay for anti-receptor binding domain (RBD) Spike IgG detection and quantification.
11
Treatment with anti CD19 CAR‐T cells is safe and effective in patients with relapsed refractory large B‐cell lymphoma with active central nervous system involvement
Fabien Le Bras,Jean-Valère Malfuson,Vincent Camus,Hugo Legendre,Romain Gounot,Karim Belhadj,David Sibon,Jehan Dupuis,Mohammad Hammoud,T. El Gnaoui,Elsa Poullot,Alexis Claudel,Dehbia Menouche,M Mebarki,Giovanna Melica,Armand Mekontso-Dessap,Paul Blanc-Durand,Stéphanie Marque,Thierry Gendre,Corinne Haioun,François Lemonnier,L. Roulin +21 more
TL;DR: Lemonnier et al. as discussed by the authors showed that CAR-T cell treatment in patients with active central nervous system involvement is associated with an extremely poor prognosis, however, data regarding efficacy and safety of CART cell treatment are limited since they are excluded from most of clinical trials.