Mohammad Fallahi
Scripps Research Institute
39 Papers
203 Citations
Mohammad Fallahi is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Transcription factor & Biology. The author has an hindex of 26, co-authored 39 publications.
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Papers
Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
Joanne R. Doherty,Chunying Yang,Kristen E.N. Scott,Michael D. Cameron,Mohammad Fallahi,Weimin Li,Mark A. Hall,Antonio L. Amelio,Jitendra Kumar Mishra,Fangzheng Li,Mariola Tortosa,Heide Marika Genau,Robert J. Rounbehler,Yunqi Lu,Chi V. Dang,K. Ganesh Kumar,Andrew A. Butler,Thomas D. Bannister,Andrea T. Hooper,Keziban Unsal-Kacmaz,William R. Roush,John L. Cleveland +21 more
TL;DR: This paper showed that myc oncoproteins induce genes driving aerobic glycolysis, including lactate dehydrogenase-A that generates lactate, and that elevated MCT1 levels are manifest in premalignant and neoplastic Eμ-Myc transgenic B cells and in human malignancies with myc or MYCN involvement.
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Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs
Matthew D. Disney,Audrey M. Winkelsas,Sai Pradeep Velagapudi,Mark R. Southern,Mohammad Fallahi,Jessica L. Childs-Disney +5 more
TL;DR: Inforna 2.0 is described, which incorporates all known RNA motif-small molecule binding partners reported in the scientific literature, a chemical similarity searching feature, and an improved user interface and is freely available via an online web server.
202
Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation
Hongkai Ji,George Wu,Xiangcan Zhan,Alexandra Nolan,Cheryl M. Koh,Angelo M. De Marzo,Hoang Mai Doan,Jinshui Fan,Christopher Cheadle,Mohammad Fallahi,John L. Cleveland,Chi V. Dang,Karen I. Zeller +12 more
TL;DR: expression of the MCS in human B cell lymphomas, acute leukemia, lung cancers or Ewing sarcomas has the highest correlation with MYC expression, andnotation of this gene signature reveals Myc's primordial function in RNA processing, ribosome biogenesis and biomass accumulation as its key roles in cancer and stem cells.
Targeting Ornithine Decarboxylase Impairs Development of MYCN-Amplified Neuroblastoma
Robert J. Rounbehler,Weimin Li,Mark A. Hall,Chunying Yang,Mohammad Fallahi,John L. Cleveland +5 more
TL;DR: It is reported that DFMO treatment, but not Odc heterozygosity, impairs MYCN-induced neuroblastoma and that, in this malignancy, transient DF MO treatment is sufficient to confer protection, suggesting that agents, such as DFMO, that target the polyamine pathway may show efficacy in high-risk, MyCN-amplified neuroblastomas.
111
Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma
Alexander Hoellein,Mohammad Fallahi,Stephanie Schoeffmann,Sabine Steidle,Franz X. Schaub,Martina Rudelius,Iina Laitinen,Lisa M. Nilsson,Andrei Goga,Christian Peschel,Christian Peschel,Jonas Nilsson,John L. Cleveland,Ulrich Keller,Ulrich Keller +14 more
TL;DR: In this article, the authors reported marked increases in the expression of genes that encode regulators and components of the SUMOylation machinery in mouse and human Myc-driven lymphomas.
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