Epidemiology of tuberculosis

Davis's Drug Guide For Nurses

Medicinal chemistry is a science applied to the search and discovery of new therapeutic agents for the treatment of various diseases Therefore, promising structures have been identified; one of these structures is the piperazine moiety, a cyclic molecule containing two nitrogen atoms in positions 1 and 4 as well as four carbon atoms Many piperazine derivatives have central pharmacological activity that mainly involves the activation of the monoamine pathway Thus, piperazine derivatives have been the subject of research for many central therapeutic applications, including antipsychotic, antidepressant and anxiolytic applications Benzylpiperazine is the prototype of piperazine derivatives; this substance is the main component of recreational drugs, partly due to its stimulant and euphoric effects This paper describes some piperazine derivatives used therapeutically as antipsychotic (clozapine), antidepressant (vortioxetine) and anxiolytic (buspirone) drugs

Piperazine derivatives with central pharmacological activity used as therapeutic tools

Exploring the detailed spectroscopic characteristics, chemical and biological activity of two cyanopyrazine-2-carboxamide derivatives using experimental and theoretical tools

The piperazine scaffold is a privileged structure frequently found in biologically active compounds. Piperazine nucleus is found in many marketed drugs in the realm of antidepressants (amoxapine), antipsychotics (bifeprunox), antihistamines (cyclizine and oxatomide), antifungals (itraconazole), antibiotics (ciprofloxacin), etc. This is one of the reasons why piperazine based compounds are gaining prominence in today's research. In addition to the ring carbons, substitution in the nitrogen atom of piperazine not only creates potential drug molecules but also makes it unique with versatile binding possibilities with metal ions. Piperazine ring-based compounds find their application in biological systems with antihistamine, anticancer, antimicrobial and antioxidant properties. They have also been successfully used in the field of catalysis and metal organic frameworks (MOFs). The present review focuses on the synthesis and application of different piperazine derivatives and their metal complexes having diverse applications.

Recent advances in the synthesis of piperazine based ligands and metal complexes and their applications

Efforts were made to synthesize different heterocyclic compounds and their derivatives and were found to posses promising pharmacological compounds. Although piperazine and pyrazine moiety is six membered heterocyclic compounds but is fascinated by scientists because of the diverse biological activities by not only piperazine and pyrazine but its various substituted derivatives as well and having diverse pharmacological activities such antitumor, anticonvulsant, antidepressant, analgesic, antimicrobial, anti?tubercular and anti diabetic, antihistamine, antiinflamatory and other activities. Some compounds also use as flavoring agent in foods. This review is focused on the piperazine and pyrazine derivatives due to its wider applications. They may replace many existing heterocyclic based pharmaceutical compounds. Many drug that containing piperazine and pyrazine moiety while several compounds are in clinical trials.

/pdf/piperazine-and-pyrazine-containing-molecules-and-their-2ej8jsbuia.pdf

Piperazine and Pyrazine containing molecules and their diverse pharmacological activities

The need of new chemotherapeutic drugs to improve tuberculosis control and treatment particularly against multidrug-resistant (MDR) and extensively drug resistant (XDR) strains of Mycobacterium. The atitubercular drugs are used in current chemotherapy have different chemical moieties. In this review, we provide an overview of the quinolone drugs as an antitubercular drug. Generally quinolone drugs are mainly used against many gram-positive and gram-negative bacterial infections including resistance strains also. Various quinolones are being used to control and treatment of tubercular infections including MDR, XDR and atypical Mycobacterium strains. Fluoroquinolones are an important quinolones, especially for strains that are resistant to first-line agents.

/pdf/role-of-quinolones-and-quinoxaline-derivatives-in-the-4pj29xq7eo.pdf

Role of quinolones and quinoxaline derivatives in the advancement of treatment of tuberculosis

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Piperazine and Pyrazine containing molecules and their diverse pharmacological activities

Role of quinolones and quinoxaline derivatives in the advancement of treatment of tuberculosis