Mohammad A. Khanfar
University of Jordan
54 Papers
325 Citations
Mohammad A. Khanfar is an academic researcher from University of Jordan. The author has contributed to research in topics: Pharmacophore & Chemistry. The author has an hindex of 19, co-authored 50 publications. Previous affiliations of Mohammad A. Khanfar include Northwestern University & University of Düsseldorf.
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Papers
Pachycladins A-E, prostate cancer invasion and migration inhibitory Eunicellin-based diterpenoids from the red sea soft coral Cladiella pachyclados.
Hossam M. Hassan,Mohammad A. Khanfar,Ahmed Y. Elnagar,Rabab Mohammed,Lamiaa A. Shaala,Diaa T. A. Youssef,Mohamed S. Hifnawy,Khalid A. El Sayed +7 more
TL;DR: Five new eunicellin diterpenes, pachycladins A-E (1-5), were isolated from the Red Sea soft coral Cladiella pachyclados and exhibited significant anti-invasive activity.
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Discovery, design, and synthesis of anti-metastatic lead phenylmethylene hydantoins inspired by marine natural products
Mudit Mudit,Mohammad A. Khanfar,Anbalagan Muralidharan,Shibu Thomas,Girish V. Shah,Rob W. M. Van Soest,Khalid A. El Sayed +6 more
TL;DR: PMH is a novel antimetastatic lead class with potential to control metastatic prostate cancer and the anti-invasive activities of all compounds were evaluated.
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Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening.
TL;DR: A multistage virtual screening strategy yielded, from among compounds in the in-house database and two commercial databases, new GSK-3β inhibitors with novel scaffold structures with nanomolar affinity and selectivity over CDK2 and were potent enough for direct in vivo validation.
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Latrunculin A and its C-17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells.
Khalid A. El Sayed,Mohammad A. Khanfar,Hassan M. Shallal,Anbalagan Muralidharan,Bhushan Awate,Diaa T. A. Youssef,Yang Liu,Yu-Dong Zhou,Dale G. Nagle,Girish V. Shah +9 more
TL;DR: The marine-derived macrolides latrunculins A and B, from the Red Sea sponge Negombata magnifica, have been found to reversibly bind actin monomers, forming a 1:1 complex with G-actin and disrupting its polymerization.
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Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells
Ioana Abraham,Sandeep Jain,Chung-Pu Wu,Mohammad A. Khanfar,Yehong Kuang,Yehong Kuang,Chun Ling Dai,Chun Ling Dai,Zhi Shi,Zhi Shi,Xiang Chen,Liwu Fu,Suresh V. Ambudkar,Khalid A. El Sayed,Zhe-Sheng Chen +14 more
TL;DR: Sipholane triterpenoids efficiently inhibit the function of P-gp through direct interactions and may represent potential reversal agents for the treatment of MDR.
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