Mohamad Karaky
Spanish National Research Council
8 Papers
Mohamad Karaky is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Genome-wide association study & Gene. The author has an hindex of 4, co-authored 5 publications.
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Papers
The multiple sclerosis-associated regulatory variant rs10877013 affects expression of CYP27B1 and VDR under inflammatory or vitamin D stimuli:
Mohamad Karaky,Antonio Alcina,María Fedetz,Cristina Barrionuevo,Victor Potenciano,Concepción Delgado,Guillermo Izquierdo,Fuencisla Matesanz +7 more
TL;DR: The MS-associated regulatory variant rs10877013 is a genetic determinant that affects the functioning of the vitamin D system linking environmental and genetic factors.
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Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel Diseases
Mohamad Karaky,Gabrielle Boucher,Saraï Mola,Sylvain Foisy,Claudine Beauchamp,Marie-Eve Rivard,Melanie Burnette,Hugues Gosselin,Alain Bitton,Guy Charron,Philippe Goyette,John D. Rioux +11 more
TL;DR: A causal role is supported for the PTGIR, ZBTB40, SLC39A11 and NFKB1 genes in IBD, with all four genes regulating the expression of CP in myeloid cells, as well as an important role for the prostacyclin/prostaglandin biogenesis and signaling pathways in I BD susceptibility and pathogenesis.
A splice variant in the ACSL5 gene relates migraine with fatty acid activation in mitochondria
Fuencisla Matesanz,María Fedetz,Cristina Barrionuevo,Mohamad Karaky,Antonio Catalá-Rabasa,Victor Potenciano,Victor Potenciano,Raquel Bello-Morales,José Antonio López-Guerrero,Antonio Alcina +9 more
TL;DR: The functional variant (rs2256368:A >G) affecting ACSL5 exon 20 skipping, as a causal factor linked to the migraine-associated rs12355831:A>G, is identified, suggesting that the activation of long-chain fatty acids by the spliced AC SL5-Δ20 molecules, a mitochondrial located enzyme, is involved in migraine pathology.
Splice-site variant in ACSL5: a marker promoting opposing effect on cell viability and protein expression
Iván Pérez-Núñez,Mohamad Karaky,María Fedetz,Cristina Barrionuevo,Guillermo Izquierdo,Fuencisla Matesanz,Antonio Alcina +6 more
TL;DR: Specific ACSL5-isoform transfection in HEK239T, U87, and HOG cells showed the Spl protein to be the causal factor of cell-growth inhibition, despite its reduced protein expression, indicating that the variant rs2256368:A>G can predict a growth inhibitory activity.
Genome-wide association study suggests a critical contribution of the adaptive immune system to chronic post-surgical pain
M. Parisien,Roel R. I. van Reij,Samar Khoury,E. Koseli,Mohamad Karaky,N. J. van den Hoogen,Marisole Allegri,Manuela De Gregori,Jamel Chelly,Barbara A. Rakel,Eske Kvanner Aasvang,H Kehlet,Wolfgang Buhre,Camron D. Bryant,Imad Damaj,Jeffrey S. Mogil,Eag Joosten,Luda Diatchenko +17 more
TL;DR: In this article , the authors performed genome-wide association studies in post-surgical cohorts of five surgery types -hysterectomy, mastectomy, abdominal, hernia, and knee- totalling 1350 individuals.
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