Mitsuhiro Yamaguchi
Daiichi Sankyo
13 Papers
42 Citations
Mitsuhiro Yamaguchi is an academic researcher from Daiichi Sankyo. The author has contributed to research in topics: Chemistry & Glucose transporter. The author has an hindex of 5, co-authored 13 publications.
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Papers
Discovery of novel pyridazine derivatives as glucose transporter type 4 (GLUT4) translocation activators.
Takashi Tsuji,Mitsuhiro Yamaguchi,Junichi Kuroyanagi,Shinji Furuzono,Masahiro Konishi,Koji Terayama,Jun Tanaka,Motoko Saito,Yoshiyuki Kobayashi +8 more
TL;DR: Promising compound 26b showed a significant blood glucose lowering effect in the severe diabetic mice model (10-week aged db/db mice) after oral dosing even at 10 mg/kg, implying that the pyridazine derivatives have potential to become novel therapeutic agents for diabetes mellitus.
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Facile Methods for Preparation of Thiazolopyridine and Tetrahydro-thiazolopyridine Derivatives
Noriyasu Haginoya,Satoshi Komoriya,Ken Osanai,Toshiharu Yoshino,Tsutomu Nagata,M. Nagamochi,Ryo Muto,Mitsuhiro Yamaguchi,Takayasu Nagahara,Hideyuki Kanno +9 more
TL;DR: In this paper, improved routes to prepare tetrahydrothiazolo[5,4-c]-pyridine-2-carboxylic acid lithium salts (2 and 3) were developed.
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Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation.
Tomoko Ogiyama,Mitsuhiro Yamaguchi,Nobuya Kurikawa,Shoko Honzumi,Yuka Yamamoto,Daisuke Sugiyama,Hideo Takakusa,Shin-ichi Inoue +7 more
TL;DR: Exchanging of this susceptible fragment was feasible, and a benzanilide derivative 6b with a decreased bioactivation liability was obtained, and Oral administration of compound 24b exhibited an antilipolytic effect on rats at 3mg/kg.
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Synthesis and structure-activity relationships of novel zwitterionic compounds as peroxisome proliferator activated receptor α/γ dual agonists with improved physicochemical properties.
Yoshihiro Shibata,Katsuji Kagechika,Mitsuhiro Yamaguchi,Kenji Yoshikawa,Kiyoshi Chiba,Hiromichi Takano,Chiyuki Akiyama,Mayumi Ono,Mina Nishi,Hideo Kubo,Yoshimasa Kobayashi,Hiroyuki Usui +11 more
TL;DR: The design, syntheses and structure-activity relationships (SAR) of novel zwitterionic compounds as non-thiazolidinedion (TZD) based peroxisome proliferator activated receptor (PPAR) α/γ dual agonists exhibited a significant decrease in plasma glucose and plasma triglyceride levels without marked weight gain.
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Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1).
TL;DR: The design, syntheses and structure-activity relationships (SAR) of novel zwitterionic compounds as non-thiazolidinedion (TZD) based peroxisome proliferator activated receptor (PPAR) α/γ dual agonists are described.
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