Mitchell Klausner
62 Papers
313 Citations
Mitchell Klausner is an academic researcher. The author has contributed to research in topics: Medicine & Wound healing. The author has an hindex of 16, co-authored 58 publications.
Chat about Author
Papers
Development of the EpiOcular(TM) eye irritation test for hazard identification and labelling of eye irritating chemicals in response to the requirements of the EU cosmetics directive and REACH legislation.
Yulia Kaluzhny,Helena Kandarova,Patrick Hayden,Joseph Kubilus,Laurence d’Argembeau-Thornton,Mitchell Klausner +5 more
TL;DR: The EpiOcular-EIT as mentioned in this paper is based on an initial training set of 39 liquid and 21 solid test substances and uses a single exposure period and a single cut-off in tissue viability, as determined by the MTT assay.
78
Organotypic human oral tissue models for toxicological studies
Mitchell Klausner,Seyoum Ayehunie,B. Breyfogle,Philip W. Wertz,Lori Ann Bacca,Joseph Kubilus +5 more
TL;DR: The oral tissue models represent highly reproducible, non-animal means to screen the irritation potential of newly developed oral care products and should be useful to study the innate immunity, biology, and pathology of the oral mucosa.
74
An in vitro skin irritation test (SIT) using the EpiDerm reconstructed human epidermal (RHE) model.
TL;DR: This procedure can be used as full replacement of the in vivo rabbit skin irritation test for hazard identification and labeling of chemicals in line with EU regulations.
63
Intralaboratory and interlaboratory evaluation of the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay
Ting Hu,Yulia Kaluzhny,Greg C. Mun,Brenda Barnett,Viktor Karetsky,Nathan Wilt,Mitchell Klausner,Rodger Curren,Marilyn J. Aardema +8 more
TL;DR: Results indicate the RSMN assay using the EpiDerm 3D human skin model is a promising new in vitro genotoxicity assay that allows evaluation of chromosome damage following "in vivo-like" dermal exposures.
62
Prevalidation of an Acute Inhalation Toxicity Test Using the EpiAirway In Vitro Human Airway Model.
George R. Jackson,Anna G. Maione,Mitchell Klausner,Patrick Hayden +3 more
- 01 Jun 2018
TL;DR: Results indicate that the EpiAirway test is a promising alternative to the currently accepted animal tests for acute inhalation toxicity, and appears to be the predominant mechanisms of toxicity for the most highly toxic chemicals.
56