Misako Hwang
Auburn University
11 Papers
44 Citations
Misako Hwang is an academic researcher from Auburn University. The author has contributed to research in topics: Sandhoff disease & Gangliosidosis. The author has an hindex of 8, co-authored 11 publications.
Chat about Author
Papers
Therapeutic Response in Feline Sandhoff Disease Despite Immunity to Intracranial Gene Therapy
Allison M. Bradbury,J. Nicholas Cochran,Victoria J. McCurdy,Aime K. Johnson,Brandon L. Brunson,Heather L. Gray-Edwards,Stanley G. LeRoy,Misako Hwang,Ashley N. Randle,Laura S Jackson,Nancy E. Morrison,Rena C. Baek,Thomas N. Seyfried,Seng H. Cheng,Nancy R. Cox,Henry J. Baker,M. Begoña Cachón-González,Timothy M. Cox,Miguel Sena-Esteves,Douglas R. Martin +19 more
TL;DR: These studies support the therapeutic potential of AAV vectors for SD and underscore the importance of species-specific cDNAs for translational research.
86
Adeno-Associated Virus Gene Therapy in a Sheep Model of Tay–Sachs Disease
Heather L. Gray-Edwards,Ashley N. Randle,Stacy Maitland,Hector R Benatti,Spencer M Hubbard,Peter F Canning,Matthew B Vogel,Brandon L. Brunson,Misako Hwang,Lauren E. Ellis,Allison M. Bradbury,Atoska S. Gentry,Amanda R. Taylor,Anne A. Wooldridge,Dewey R. Wilhite,Randolph L. Winter,Brian K Whitlock,Jacob A. Johnson,Merilee Holland,Nouha Salibi,Ronald J. Beyers,James L. Sartin,Thomas S. Denney,Nancy R. Cox,Miguel Sena-Esteves,Douglas R. Martin +25 more
TL;DR: This report demonstrates therapeutic efficacy for TSD in the sheep brain, which is on the same order of magnitude as a child's brain.
76
Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease
Victoria J. McCurdy,Hannah E. Rockwell,Julian R. Arthur,Allison M. Bradbury,Aime K. Johnson,Ashley N. Randle,Brandon L. Brunson,Misako Hwang,Heather L. Gray-Edwards,Nancy E. Morrison,Jacob A. Johnson,Henry J. Baker,Nancy R. Cox,Thomas N. Seyfried,Miguel Sena-Esteves,Douglas R. Martin +15 more
TL;DR: In this article, Adeno-associated virus (AAV) gene therapy achieved global CNS Hex restoration and widespread normalization of storage in the Sandhoff disease (SD) mouse model using a similar treatment approach, and they sought to translate the outcome in mice to the feline SD model as an important step toward human clinical trials.
72
Neurodegenerative lysosomal storage disease in European Burmese cats with hexosaminidase β-subunit deficiency
Allison M. Bradbury,Nancy E. Morrison,Misako Hwang,Nancy R. Cox,Henry J. Baker,Douglas R. Martin +5 more
TL;DR: Thin layer chromatography revealed substantial storage of GM2 ganglioside in brain tissue of affected cats, and assays with a synthetic fluorogenic substrate confirmed the absence of hexosaminidase activity.
51
Molecular consequences of the pathogenic mutation in feline GM1 gangliosidosis
Douglas R. Martin,Brigitte Rigat,Polly Foureman,G.S. Varadarajan,Misako Hwang,Barbara K. Krum,Bruce F. Smith,John W. Callahan,Don J. Mahuran,Henry J. Baker +9 more
TL;DR: Feline beta-galactosidase messenger RNA levels were normal in cerebral cortex, as determined by quantitative RT-PCR assays, and G(M1) cat fibroblasts demonstrated increased expression of glucose-related protein 78/BiP and protein disulfide isomerase, suggesting that the unfolded protein response plays a role in pathogenesis of feline G( M1) gangliosidosis.
45