Mirna Castro
Ludwig Maximilian University of Munich
6 Papers
44 Citations
Mirna Castro is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Myoclonus & Dystonia. The author has an hindex of 5, co-authored 6 publications.
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Papers
Expression of Indoleamine 2,3-Dioxygenase in Tumor Endothelial Cells Correlates with Long-term Survival of Patients with Renal Cell Carcinoma
Rainer Riesenberg,Christoph Weiler,Oliver Spring,Martin Eder,Alexander Buchner,Tanja Popp,Mirna Castro,Robert Kammerer,Osamu Takikawa,Rudolf Hatz,Christian G. Stief,Alfons Hofstetter,Wolfgang Zimmermann +12 more
TL;DR: IDO in endothelial cells might limit the influx of tryptophan from the blood to the tumor or generate tumor-toxic metabolites, thus restricting tumor growth and contributing to survival.
175
Downregulation of HNF-1B in Renal Cell Carcinoma Is Associated With Tumor Progression and Poor Prognosis
Alexander Buchner,Mirna Castro,Anja Hennig,Tanja Popp,Gerald Assmann,Christian G. Stief,Wolfgang Zimmermann +6 more
TL;DR: HNF-1B might be a useful prognostic factor for metastatic RCC and also a potential therapeutic target in the future, and patients with high HNF- 1B mRNA levels have a significantly better prognosis.
41
Point mutations in exon 1 of the NR4A2 gene are not a major cause of familial Parkinson's disease.
Alexander Zimprich,Friedrich Asmus,Petra Leitner,Mirna Castro,Benjamin Bereznai,Nikolaus Homann,Erwin Ott,A. Wijnand F. Rutgers,Gyri Wieditz,Claudia Trenkwalder,Thomas Gasser +10 more
TL;DR: The findings show that sequence alterations in exon 1 of the NR4A2 gene are not a major cause of familial PD in central Europe, and no mutations were found in the 30 families with known parent-child transmission.
40
Transkriptomanalysen beim Nierenzellkarzinom
Alexander Buchner,Mirna Castro,Anja Hennig,Tanja Popp,Gerald Assmann,Alfons Hofstetter,C.G. Stief,Wolfgang Zimmermann +7 more
TL;DR: In RCC the combination of laser microdissection and subsequent microarray analysis provides reliable data from precisely defined material and is an optimal starting point for the development of novel therapeutic and diagnostic options.
5
Mutations in the gene encoding epsilon-sarcoglycan cause myoclonus-dystonia syndrome.
Alexander Zimprich,Monika Grabowski,Friedrich Asmus,Markus Naumann,Daniela Berg,M. Bertram,Karl Scheidtmann,Peter Kern,Juliane Winkelmann,Bertram Müller-Myhsok,Leonhard Riedel,Matthias F. Bauer,Tanja Müller,Mirna Castro,Thomas Meitinger,Tim M. Strom,Thomas Gasser +16 more
TL;DR: Using a positional cloning approach, five different heterozygous loss-of-function mutations in the gene for ɛ-sarcoglycan (SGCE) are identified, which is mapped to a refined critical region of about 3.2 Mb and shows a marked difference in penetrance depending on the parental origin of the disease allele.