Mirko Kummer
University of Erlangen-Nuremberg
22 Papers
151 Citations
Mirko Kummer is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Antigen & Virus. The author has an hindex of 10, co-authored 18 publications.
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Papers
Herpes Simplex Virus Type 1 Induces CD83 Degradation in Mature Dendritic Cells with Immediate-Early Kinetics via the Cellular Proteasome
Mirko Kummer,Nadine Turza,Petra Mühl-Zürbes,Matthias Lechmann,Chris Boutell,Robert S. Coffin,Roger D. Everett,Alexander Steinkasserer,Alexander Prechtel +8 more
TL;DR: Inhibition of the proteasome, the cellular protein degradation machinery, almost completely restored CD83 surface expression during HSV-1 infection, indicating that proteasomesome-mediated degradation and HSv-1 ICP0 play crucial roles in this novel viral immune escape mechanism.
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Autologous regulatory T-cell transfer in refractory ulcerative colitis with concomitant primary sclerosing cholangitis
Caroline J. Voskens,Diane Stoica,M. Rosenberg,Francesco Vitali,Sebastian Zundler,Marion Ganslmayer,Heike Knott,Manuel Wiesinger,J. Wunder,Mirko Kummer,Britta Siegmund,Elisabeth Schnoy,Timo Rath,Arndt Hartmann,Holger Hackstein,Beatrice Schuler-Thurner,Carola Berking,Gerold Schuler,Raja Atreya,Markus F. Neurath +19 more
TL;DR: It is suggested that adoptive Treg therapy might be effective in refractory UC and might open new avenues for clinical trials in PSC.
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Autophagic degradation of lamins facilitates the nuclear egress of herpes simplex virus type 1.
Aykut Turan,Linda Grosche,Adalbert Krawczyk,Petra Mühl-Zürbes,Christina Drassner,Alexandra Düthorn,Mirko Kummer,Mike Hasenberg,Sylvia Voortmann,Holger Jastrow,Jan Dörrie,Niels Schaft,Max E. Kraner,Katinka Döhner,Beate Sodeik,Alexander Steinkasserer,Christiane Silke Heilingloh +16 more
TL;DR: It is hypothesized that inhibition of autophagic lamin degradation in mDCs represents a very powerful cellular counterstrike to inhibit the production of progeny virus and thus viral spread.
Herpes simplex virus type 1 ICP0 induces CD83 degradation in mature dendritic cells independent of its E3 ubiquitin ligase function.
TL;DR: Evidence is provided that ubiquitination of lysine residues is, despite the published E3 ubiquitin ligase activity of ICP0, not necessary for CD83 degradation, which provides strong evidence that I CP0 alone inducesCD83 degradation independent of its E3 ubiquitous ligase function and of the Ubiquitin machinery.
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Infection of mature dendritic cells with herpes simplex virus type 1 interferes with the interferon signaling pathway.
TL;DR: It is shown that HSV-1 blocks IFN-gamma signaling in mDCs, which requires viral gene expression and involves the viral protein vhs.
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