Mirjam Eckert
University of Edinburgh
4 Papers
Mirjam Eckert is an academic researcher from University of Edinburgh. The author has contributed to research in topics: IRF1 & Transcription factor. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Mirjam Eckert include Edinburgh Cancer Research Centre & Western General Hospital.
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Papers
Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53.
David Dornan,Mirjam Eckert,Maura Wallace,Harumi Shimizu,Eleanor Ramsay,Ted R. Hupp,Kathryn L. Ball +6 more
TL;DR: The data expand the core p300-p53 protein LXXLL and PXXP interface by including an IRF-1-p300 interface as an allosteric modifier of DNA-dependent acetylation of p53 at the p21 promoter.
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Role of the IRF-1 enhancer domain in signalling polyubiquitination and degradation
TL;DR: A role for discrete motifs in the enhancer domain of IRF-1 in directing polyubiquitination and degradation is established and support is given to the idea that the degradation of selective substrates can be regulated at multiple steps in the ubiquitin-proteasome system.
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A novel repressor domain is required for maximal growth inhibition by the IRF-1 tumor suppressor.
TL;DR: It is shown that IRF-1-mediated growth inhibition is dependent on the integrity of a C-terminal transcriptional enhancer domain and an enhancer subdomain (amino acids 301-325) that differentially regulates IRf-1 activity has been identified and this region mediates the repression of Cdk2.
26
Cooperative Regulation of the Interferon Regulatory Factor-1 Tumor Suppressor Protein by Core Components of the Molecular Chaperone Machinery
TL;DR: The role of the Mf1 domain of IRF-1 is elucidated in orchestrating the recruitment of regulatory factors that can impact on both its turnover and transcriptional activity.