Mirian Ueno
State University of Campinas
31 Papers
515 Citations
Mirian Ueno is an academic researcher from State University of Campinas. The author has contributed to research in topics: Insulin & Insulin receptor. The author has an hindex of 22, co-authored 31 publications.
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Papers
S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance.
Marco Antonio de Carvalho-Filho,Mirian Ueno,Sandro M. Hirabara,Amedea B. Seabra,José B.C. Carvalheira,Marcelo Ganzarolli de Oliveira,Licio A. Velloso,Rui Curi,Mario J.A. Saad +8 more
TL;DR: S-nitrosation of proteins involved in insulin signal transduction is a novel molecular mechanism of iNOS-induced insulin resistance and yielded an improvement in insulin action in both animal models.
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Western Diet Modulates Insulin Signaling, c-Jun N-Terminal Kinase Activity, and Insulin Receptor Substrate-1ser307 Phosphorylation in a Tissue-Specific Fashion
Patrícia O. Prada,Henrique Gottardello Zecchin,Alessandra L. Gasparetti,Marcio Alberto Torsoni,Mirian Ueno,Aparecida Emiko Hirata,Maria Esméria Corezola do Amaral,Nelci Fenalti Hoer,Antonio Carlos Boschero,Mario J.A. Saad +9 more
TL;DR: The insulin resistance induced by WD is tissue specific and installs first in hypothalamus and muscle and later in liver, accompanied by activation of JNK and IRS-1(ser307) phosphorylation.
Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway.
Mirian Ueno,José B.C. Carvalheira,Rosa C. Tambascia,Rosângela Maria Neves Bezerra,Maria Esméria Corezola do Amaral,Everardo M. Carneiro,Franco Folli,Kleber G. Franchini,Mja Saad +8 more
TL;DR: Evidence is provided that chronic hyperinsulinaemia itself, imposed on normal rats, appears to have a dual effect, stimulating insulin signalling in white adipose tissue, whilst decreasing it in liver and muscle, and the hypothesis that defective and tissue-selective insulin action contributes to the insulin resistance observed in hyperinsulaemic states is supported.
A high fructose diet affects the early steps of insulin action in muscle and liver of rats.
Rosângela Maria Neves Bezerra,Mirian Ueno,Maria Silene da Silva,Débora de Queiroz Tavares,Carla Roberta de Oliveira Carvalho,Mario J.A. Saad +5 more
- 01 Jun 2000
TL;DR: Data suggest that changes in the early steps of insulin signal transduction may have an important role in the insulin resistance observed in these rats.
182
Exercise Improves Insulin and Leptin Sensitivity in Hypothalamus of Wistar Rats
Marcelo B.S. Flores,Maria Fernanda A. Fernandes,Eduardo R. Ropelle,Marcel C. Faria,Mirian Ueno,Licio A. Velloso,Mario J.A. Saad,José B.C. Carvalheira +7 more
TL;DR: Support is provided for the hypothesis that the appetite-suppressive actions of exercise may be mediated by the hypothalamus by showing that intracerebroventricular insulin or leptin infusion reduced food intake in exercised rats to a greater extent than that observed in control animals.
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