Miranda W Yu
4 Papers
Miranda W Yu is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 4 publications.
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Papers
Single-cell spatial immune landscapes of primary and metastatic brain tumours
Elham Karimi,Miranda W Yu,Sarah M. Maritan,Lucas J. M. Perus,Morteza Rezanejad,Mark Sorin,Matthew Dankner,Parvane Fallah,Samuel Doré,Dongmei Zuo,Benoit Fiset,Daan Kloosterman,LeeAnn Ramsay,Yuhong Wei,Stephanie Lam,Roa Alsajjan,Ian R. Watson,Gloria B. Roldán Urgoiti,Morag Park,Dieta Brandsma,Donna L. Senger,Jennifer A. Chan,Leila Akkari,Kevin Petrecca,Marie-Christine Guiot,Peter M. Siegel,Daniela F. Quail,Logan A. Walsh +27 more
TL;DR: In this article , the authors applied imaging mass cytometry to characterize the immunological landscape of 139 high-grade glioma and 46 brain metastasis tumours from patients, revealing differences in immune landscapes between primary tumours and brain metastases from diverse solid cancers.
Single-cell spatial landscapes of the lung tumour immune microenvironment
Mark Sorin,Morteza Rezanejad,Elham Karimi,Benoit Fiset,Lysanne Desharnais,Lucas J. M. Perus,Simon Milette,Miranda W Yu,Sarah M. Maritan,Samuel Doré,Émilie Pichette,William Palmer Enlow,Andréanne Gagné,Yuhong Wei,Michèle Orain,Venkata S. K. Manem,Roni F. Rayes,Peter M. Siegel,Sophie Camilleri-Broët,Pierre Fiset,Patrice Desmeules,Jonathan Spicer,Daniela F. Quail,Philippe Joubert,Logan A. Walsh +24 more
TL;DR: In this article , the authors apply imaging mass cytometry to characterize the tumour and immunological landscape of samples from 416 patients with lung adenocarcinoma across five histological patterns.
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Obesity alters monocyte developmental trajectories to enhance metastasis.
Sheri A. C. McDowell,Simon Milette,Samuel Doré,Miranda W Yu,Mark Sorin,Lysanne Desharnais,Ozgun Varol,Anikka M. Swaby,Valérie Breton,Azadeh Arabzadeh,Sarah Petrecca,Aanya Bhagrath,Meghan L De Meo,Katherine D. Lach,Marianne Samir M. Issac,Benoit Fiset,Roni F. Rayes,Judith N. Mandl,Jörg H. Fritz,Pierre Olivier Fiset,Andrew J. Dannenberg,Jonathan Spicer,Logan A. Walsh,Daniela F. Quail +23 more
TL;DR: In this paper , the authors show that obesity-induced monocytes underlie neutrophil activation and breast cancer lung metastasis and provide mechanistic insight into the relationship between obesity and cancer by broadening their understanding of the interactive role that myeloid cells play in this process.
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Abstract 69: Minimally invasive brain metastases are characterized by elevated immune cell infiltrate
Sarah M. Maritan,Elham Karimi,Matthew Dankner,Miranda W Yu,Aldo Hernandez-Corchado,Morteza Rezanejad,Parvane Fallah,Benoit Fiset,Yuhong Wei,Stephanie Lam,Alissar Nehmé,Ian R. Watson,Morag Park,Yasser Riazalhosseini,Hamed S. Najafabadi,Kevin Petrecca,Marie-Christine Guiot,Daniela F. Quail,Logan A. Walsh,Peter M. Siegel +19 more
TL;DR: Maritan et al. as mentioned in this paper investigated how the tumor immune microenvironments (TIME) between these two lesion types remain largely unknown, and found that HI BrM invade into an immunosuppressed microenvironment while MI BrM are characterized by an active anti-tumor immune infiltrate.