Miranda Batchelor
Imperial College London
13 Papers
287 Citations
Miranda Batchelor is an academic researcher from Imperial College London. The author has contributed to research in topics: Intimin & Enteropathogenic Escherichia coli. The author has an hindex of 11, co-authored 13 publications.
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Papers
Identification of CesT, a chaperone for the type III secretion of Tir in enteropathogenic Escherichia coli.
Simon J. Elliott,Steven W. Hutcheson,Steven W. Hutcheson,Maria S. Dubois,Jay L. Mellies,Leslie A. Wainwright,Miranda Batchelor,Gad Frankel,Stuart Knutton,James B. Kaper +9 more
TL;DR: Based upon the physical similarities, phenotypic characteristics and the demonstrated interaction with Tir, orfU is redesignated as cesT for the chaperone for E. coli secretion of T’ir.
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Involvement of the intermediate filament protein cytokeratin-18 in actin pedestal formation during EPEC infection
Miranda Batchelor,Julie Guignot,Amit Patel,Nicola J. Cummings,Jennifer Cleary,Stuart Knutton,David W. Holden,Ian F. Connerton,Gad Frankel +8 more
TL;DR: This study is the first to implicate intermediate filaments in microfilament reorganization following EPEC infection and identifies cytokeratin 18 as a novel Tir partner protein.
Development of a Universal Intimin Antiserum and PCR Primers
Miranda Batchelor,Stuart Knutton,Alfredo Caprioli,Veronika Huter,Mazlina Zanial,Gordon Dougan,Gad Frankel +6 more
TL;DR: Using a conserved region of the intimin molecule and primers synthesized to generate the recombinant Int388–667, universal intimin antiserum and PCR primers that are reactive with the different intimin types expressed by both human and animal A/E lesion-forming strains are generated.
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Generation of Escherichia coli intimin derivatives with differing biological activities using site‐directed mutagenesis of the intimin C‐terminus domain
TL;DR: It is reported that intimin‐mediated A/E lesion formation can be segregated from intimin-mediated HEp‐2 cell invasion and adherence to IVOC, EPEC‐induced microvillus elongation and colonization of the murine intestine by C. rodentium were also modulated by the modified intimins.
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Antibody response of patients infected with verocytotoxin-producing Escherichia coli to protein antigens encoded on the LEE locus
Claire Jenkins,Henrik Chart,Henry R. Smith,Elizabeth L. Hartland,Miranda Batchelor,Robin M. Delahay,G. Dougan,Gad Frankel +7 more
TL;DR: Antibodies to proteins involved in expressing the attaching and effacing phenotype may form the basis of a serodiagnostic test for the detection of patients infected with VTEC which carry the locus for the enterocyte effacement pathogenicity island and provide an adjunct test to the established serological tests based on VTEC LPS.
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