Skin injuries across the body continue to disrupt everyday life for millions of patients and result in prolonged hospital stays, infection, and death. Advances in wound healing devices have improved clinical practice but have mainly focused on treating macroscale healing versus underlying microscale pathophysiology. Consensus is lacking on optimal treatment strategies using a spectrum of wound healing products, which has motivated the design of new therapies. We summarize advances in the development of novel drug, biologic products, and biomaterial therapies for wound healing for marketed therapies and those in clinical trials. We also share perspectives for successful and accelerated translation of novel integrated therapies for wound healing.

https://www.science.org/doi/pdf/10.1126/sciadv.ade7007?download=true

Breakthrough treatments for accelerated wound healing

Bioadhesives have emerged as transformative and versatile tools in healthcare, offering the ability to attach tissues with ease and minimal damage. These materials present numerous opportunities for tissue repair and biomedical device integration, creating a broad landscape of applications that have captivated clinical and scientific interest alike. However, fully unlocking their potential requires multifaceted design strategies involving optimal adhesion, suitable biological interactions, and efficient signal communication. In this Review, we delve into these pivotal aspects of bioadhesive design, highlight the latest advances in their biomedical applications, and identify potential opportunities that lie ahead for bioadhesives as multifunctional technology platforms.

Bioadhesive Technology Platforms.

The eye contains a complex network of physiological information and biomarkers for monitoring disease and managing health, and ocular devices can be used to effectively perform point-of-care diagnosis and disease management. This comprehensive review describes the target biomarkers and various diseases, including ophthalmic diseases, metabolic diseases, and neurological diseases, based on the physiological and anatomical background of the eye. This review also includes the recent technologies utilized in eye-wearable medical devices and the latest trends in wearable ophthalmic devices, specifically smart contact lenses for the purpose of disease management. After introducing other ocular devices such as the retinal prosthesis, we further discuss the current challenges and potential possibilities of smart contact lenses.

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

Wound management materials and technologies from bench to bedside and beyond

Abstract Chronic wounds have become a significant threat to people's physical and mental health and have increased the burden of social medical care. Intelligent wound dressing (IWD) with wound condition monitoring and closed‐loop on‐demand drug therapy can shorten the healing process and alleviate patient suffering. However, single‐function wound dressings cannot meet the current needs of chronic wound treatment. Here, a wearable IWD consisting of wound exudate management, sensor monitoring, closed‐loop therapy, and flexible circuit modules is reported, which can achieve effective synergy between wound exudate management and on‐demand wound therapy. The dressing is attached to the wound site, and the wound exudate is spontaneously pumped into the microfluidic channel for storage. Meanwhile, the IWD can detect the state of the wound through the temperature and humidity sensor, and use this as feedback to control the liquid metal (LM) heater through a smartphone, thereby realizing the on‐demand drug release from the hydrogel. In a mouse model of infected wounds, IWD accelerates wound healing by reducing inflammatory responses, promoting angiogenesis and collagen deposition. 

Wireless and Closed-Loop Smart Dressing for Exudate Management and On-demand Treatment of Chronic Wounds.

Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.

Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites

This paper introduces the Are u Depressed (AuD) model, which aims to detect depressive emotional intensity and classify detailed depressive symptoms expressed in user utterances. The study includes the creation of a BWS dataset using a tool for the Best-Worst Scaling annotation task and a DSM-5 dataset containing nine types of depression annotations based on major depressive disorder (MDD) episodes in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The proposed model employs the DistilBERT model for both tasks and demonstrates superior performance compared to other machine learning and deep learning models. We suggest using our model for real-time depressive emotion detection tasks that demand speed and accuracy. Overall, the AuD model significantly advances the accurate detection of depressive emotions in user utterances.

/pdf/are-you-depressed-analyze-user-utterances-to-detect-3v4nkt0z.pdf

Are You Depressed? Analyze User Utterances to Detect Depressive Emotions Using DistilBERT

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Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites

Are You Depressed? Analyze User Utterances to Detect Depressive Emotions Using DistilBERT