Minoru Sasaki
5 Papers
46 Citations
Minoru Sasaki is an academic researcher. The author has contributed to research in topics: Steatohepatitis & Hepatitis. The author has an hindex of 3, co-authored 5 publications.
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Papers
Longitudinal analysis of murine steatohepatitis model induced by chronic exposure to high-fat diet.
Makoto Ito,Jun Suzuki,Shigeharu Tsujioka,Minoru Sasaki,Akira Gomori,Takashi Shirakura,Hiroyasu Hirose,Masahiko Ito,Akane Ishihara,Hisashi Iwaasa,Akio Kanatani +10 more
TL;DR: This paper found that long-term high-fat diet (HFD) exposure induces NASH, with excess body weight, hyperinsulinemia and hypercholesteremia in mice.
252
Development of nonalcoholic steatohepatitis model through combination of high-fat diet and tetracycline with morbid obesity in mice.
Makoto Ito,Jun Suzuki,Minoru Sasaki,Keiko Watanabe,Shigeharu Tsujioka,Yuki Takahashi,Akira Gomori,Hiroyasu Hirose,Akane Ishihara,Hisashi Iwaasa,Akio Kanatani +10 more
TL;DR: In this article, the authors tried to develop a new murine model of NASH with metabolic abnormalities based on the "two hit theory", where the first hit to achieve metabolic abnormalities, a high-fat diet (HFD: 60 cal% fat) was fed to C57BL/6 mice for 10 weeks and the second hit, 30mg/kg tetracycline was injected intraperitoneally once daily for 10 days.
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Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice.
Makoto Ito,Akira Gomori,Jun Suzuki,Shigeharu Tsujioka,Minoru Sasaki,Masao Matsuda,Maria A. Bednarek,Masahiko Ito,Akane Ishihara,Hisashi Iwaasa,Douglas J. MacNeil,Akio Kanatani +11 more
TL;DR: It is suggested that brain blockade of MCH1R could alleviate steatohepatitis independently from anti-obesity effects, and could have a new therapeutic potential for the treatment of human nonalcoholic steato hepatitis.
Patent
Pathologic model animal for non-alcoholic fatty hepatitis
Jun Suzuki,Hisashi Iwaasa,Minoru Sasaki,Makoto Ito,Akio Kanatani +4 more
- 13 Sep 2005
TL;DR: In this paper, a pathologic model animal for non-alcoholic steatohepatitis produced by continuously administering a tetracycline antibiotic to an animal having its body weight significantly increased compared with that of a group fed with a normal diet by feeding it with a high-fat diet.
3
Patent
Pathological Animal Model For Non-Alcoholic Fatty Hepatitis
Jun Suzuki,Hisashi Iwaasa,Minoru Sasaki,Makoto Ito,Akio Kanatani +4 more
- 13 Sep 2005
TL;DR: In this article, the authors presented a pathologic model animal for non-alcoholic steatohepatitis produced by continuously administering a tetracycline antibiotic to an animal having its body weight significantly increased compared with that of a group fed with a normal diet.
2