Propolis: is there a potential for the development of new drugs?

Propolis is a natural product derived from plant resins collected by honeybees. It is used by bees as glue, a general-purpose sealer, and as draught-extruder for beehives. Propolis has been used in folk medicine for centuries. It is known that propolis possesses anti-microbial, antioxidative, anti-ulcer and anti-tumor activities. Therefore, propolis has attracted much attention in recent years as a useful or potential substance used in medicine and cosmetics products. Furthermore, it is now extensively used in foods and beverages with the claim that it can maintain or improve human health. The chemical composition of propolis is quite complicated. More than 300 compounds such as polyphenols, phenolic aldehydes, sequiterpene quinines, coumarins, amino acids, steroids and inorganic compounds have been identified in propolis samples. The contents depend on the collecting location, time and plant source. Consequently, biological activities of propolis gathered from different phytogeographical areas and time periods vary greatly. In this review, the activity of bee propolis will be presented with special emphasis on the antitumor activity.

/pdf/biological-activity-of-bee-propolis-in-health-and-disease-471vc0a6nt.pdf

Biological activity of bee propolis in health and disease.

Propolis is a potential source of natural antioxidants such as phenolic acids and flavonoids. Its wide biological effects have been known and used since antiquity. In the modern world natural substances are sought which would be able to counteract the effects of antioxidative stress, which underlies many diseases, such as cancer, diabetes and atherosclerosis. This paper aims to present the antioxidative activity of phenolic acids and flavonoids present in Polish propolis and the relationship between their chemical structure and antioxidative activity influencing its medicinal properties. Data concerning the biological activity of propolis are summarized here, including its antibacterial, anti-inflammatory, anticarcinogenic, antiatherogenic, estrogenic effects, as well as AIDS- counteracting and reparative-regenerative function.

http://www.molvis.org/molvis/v19/78/mv-v19-78.pdf

Structure and antioxidant activity of polyphenols derived from propolis.

Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease: Running title: Propolis against SARS-CoV-2 infection and COVID-19.

Propolis is a resin produced by honeybees by mixing wax, pollen, salivary secretions, and collected natural resins. The precise composition of propolis varies with the source, and over 300 chemical components belonging to the flavonoids, terpenes, and phenolic acids have been identified in propolis. Moreover, its chemical composition is subjected to the geographical location, botanical origin, and bee species. Propolis and its compounds have been the focus of many works due to their antimicrobial and anti-inflammatory activity; however, it is now recognized that propolis also possesses regenerative properties. There is an increasing interest in the healing potential of natural products, considering the availability and low cost of these products. Propolis contains a huge number of compounds that explicate some biological effects that speeds up the healing process and is widely used in folk remedies. This review aims to condense the results on the mechanism of activity of propolis and its compounds.

/pdf/propolis-a-new-frontier-for-wound-healing-2359m343aw.pdf

Propolis: a new frontier for wound healing?

Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus

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Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus