Mingzu Zhang
Soochow University (Suzhou)
80 Papers
665 Citations
Mingzu Zhang is an academic researcher from Soochow University (Suzhou). The author has contributed to research in topics: Prodrug & Micelle. The author has an hindex of 26, co-authored 80 publications. Previous affiliations of Mingzu Zhang include Fudan University.
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Papers
Rapidly in situ forming polyphosphoester-based hydrogels for injectable drug delivery carriers
TL;DR: The preparation and characterization of a series of rapidly in situ forming and pH-responsive hydrogels with different crosslinking degrees achieved by accelerated free radical copolymerization of polyphosphoester-based macrocrosslinker and 2-(dimethylamino)ethyl methacrylate (DMAEMA) monomer show great potential as injectable drug delivery system.
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Galactosylated biodegradable poly(ε-caprolactone-co-phosphoester) random copolymer nanoparticles for potent hepatoma-targeting delivery of doxorubicin
TL;DR: Results show that these biodegradable Gal-decorated poly(CL-co-OPEA-Gal) nanoparticles are highly promising for targeted delivery of water-insoluble anti-cancer drugs for hepatocellular carcinoma.
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Facile approach for DNA encapsulation in functional polyion complex for triggered intracellular gene delivery: design, synthesis, and mechanism.
TL;DR: The results indicate that the prepared microcapsules may remain stable during systemic circulation, but degrade and release the carried DNA in a cellular reducing environment.
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Facile preparation of pH-responsive PEGylated prodrugs for activated intracellular drug delivery
TL;DR: The cytotoxicity and intracellular uptake assays revealed that the PEGylated acid-sensitive prodrugs could rapidly internalized by HeLa or HepG2 cells to release DOX and effectively inhibited the proliferation of the tumor cells, which have the potential for use in cancer therapy.
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Injectable supramolecular hydrogels fabricated from PEGylated doxorubicin prodrug and α-cyclodextrin for pH-triggered drug delivery
TL;DR: The results of the pH-responsive property, in vitro cytotoxicity and drug release revealed that the supramolecular hydrogels can be used as a potential injectable matrix for the encapsulation and controlled release of anticancer drugs.
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