Mingyu Gan

TL;DR: Wang et al. as discussed by the authors characterized the global diversity of the Beijing family based on whole-genome sequences of 358 Beijing strains and showed that the Beijing strains endemic in East Asia are genetically diverse, whereas the globally emerging strains mostly belong to a more homogenous subtype known as "modern" Beijing sublineage.

TL;DR: Analysis of 4,578 Mycobacterium tuberculosis isolates reveals the evolutionary history of the four tuberculosis genotypes in China, from emergence 1,000 years ago to expansion, population peaks and, more recently, dominance of the indigenous sublineage L2.3.

TL;DR: The primary mechanism driving local incidence of tuberculosis in urban centres is local transmission between both migrants and residents, and more than two-thirds of migrants in genomic clusters were infected locally after migration.

TL;DR: The “modern” Beijing sublineage experienced massive expansions in northern China during the Neolithic era and subsequently spread to other regions following the migration of Han Chinese, supporting a parallel evolution of the Beijing family and modern humans in East Asia.