Mingxing Wang
Shenyang Pharmaceutical University
10 Papers
13 Citations
Mingxing Wang is an academic researcher from Shenyang Pharmaceutical University. The author has contributed to research in topics: Pharmacophore & Docking (molecular). The author has an hindex of 5, co-authored 8 publications.
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Papers
In silico exploration of aryl sulfonamide analogs as voltage-gated sodium channel 1.7 inhibitors by using 3D-QSAR, molecular docking study, and molecular dynamics simulations.
TL;DR: This research performed molecular simulation works on a series of classic aryl sulfonamide Nav1.7 inhibitors using three-dimensional quantitative structure-activity relationships (3D-QSAR), molecular docking and molecular dynamics simulations for the first time to explore the correlation between their structures and activities.
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Computational investigation of imidazopyridine analogs as protein kinase B (Akt1) allosteric inhibitors by using 3D-QSAR, molecular docking and molecular dynamics simulations
TL;DR: Molecular modeling methods including molecular docking, three-dimensional quantitative structure–activity relationship (3 D-QSAR) and molecular dynamics simulation were applied on a series of Akt1 allosteric inhibitors to explore the structural requirements for their activities.
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Identification of isobavachalcone as a potential drug for rice blast disease caused by the fungus Magnaporthe grisea.
TL;DR: IBC owns significant agonistic activity in chitinase and would be a potent fungicide to inhibit the growth of M. grisea, according to this study.
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Hydrofracture plugging mechanisms and evaluation methods during temporary plugging and diverting fracturing
TL;DR: Wang et al. as mentioned in this paper investigated the fracture plugging effects influenced by the uneven distribution of net pressure within the fracture and established a 2D XFEM model to evaluate the fracture-plugging effect.
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Discovery of novel benzimidazole derivatives as potent potassium-competitive acid blockers for the treatment of acid-related diseases.
Mingxing Wang,Chenxi Zhang,Zhihao Zhang,Xiao-ya Xu,Yi He,Yuqing Hu,Yan Lin Wang,Yang Liu,Mingyu Xia,Maosheng Cheng +9 more
TL;DR: In this paper , a series of benzimidazole derivatives were designed and synthesized through conformational restriction and skeleton hopping strategies by using vonoprazan as the lead compound.
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