The invention relates to a novel controlled release pellet preparation and its preparation method, and especially relates to a tamsulosin hydrochloride controlled release pellet preparation and its preparation method. The controlled release pellet adopts a drug-loaded controlled release layer to coat a blank pellet and an enteric coating to coat the drug-loaded controlled release layer in order to control the drug release, the drug release can be realized in an acidic or weakly alkaline environment, and good absorption is realized when the pellet enters a body. The pellet has the advantages of good release degree homogeneity, simple preparation technology and good repeatability. The invention further provides a novel drug controlled release pellet suitable for small-dimension drugs. The novel drug controlled release pellet still well controls the drug release when the drug load amount reduces to 10% or less of a total weight.

Controlled release pellet preparation and its preparation method

The invention discloses a tamsulosin hydrochloride sustained-release pellet preparation. The tamsulosin hydrochloride sustained-release pellet preparation comprises a tamsulosin hydrochloride sustained-release pellet core, a sustained-release coating layer, and an enteric soluble coating layer; and is a capsule preparation. Three slow release methods including skeleton slow-release, membrane control slow-release, and enteric coating are adopted for preparation of the tamsulosin hydrochloride sustained-release pellet preparation; the obtained tamsulosin hydrochloride sustained-release pellet capsule preparation is capable of controlling releasing from the stomach to the intestine, so that adverse reaction caused by large amount absorption of tamsulosin hydrochloride in a short time is prevented. A preparation method of the tamsulosin hydrochloride sustained-release pellet preparation is simple; and in vivo release of tamsulosin hydrochloride can be controlled stably and effectively.

Tamsulosin hydrochloride sustained-release pellet preparation

The invention provides a tamsulosin sustained-release pellet, and the drug release of the sustained-release pellet is controlled through a blank pellet core coated with a drug-loaded sustained-release layer and then coated with an enteric coating, and the drug can be both released in an acidic or weak alkaline environment and is absorbed well in vivo. Also, release homogeneity is good, preparation technology is simple and repeatability is good.

Tamsulosin sustained-release pellet preparation and preparation method thereof

The invention provides a tamsulosin sustained release pellet. The tamsulosin sustained release pellet comprises a medicine-containing pellet core and a sustained release coating layer, wherein the sustained release coating layer comprises a hydrophobic matrix and a hydrophilic polymer which is sensitive to pH values. The pH values of a high molecular polymer in the dissolving process are 1 to 14, so that medicines are released at different pH values; and simultaneously, the high molecular polymer can be used as a carrier for controlling tamsulosin to be released, so that a prescription is simplified, preparation difficulties are reduced, and the tamsulosin sustained release pellet is easy to industrially produce in batches. Surprisingly, the preparation can be used for preparing various tamsulosin sustained release formulations without dependence on the physicochemical property of the tamsulosin.

Tamsulosin sustained release pellet and preparation method thereof

The invention relates to a drug sustained-release pellet which changes drug release behavior and a method for preparing the same. The sustained-release pellet comprises a pill-contained core and a sustained-release coating layer, wherein the sustained-release coating layer comprises hydrophobic matrix and hydrophilic polymer which is sensitive to pH value. The macromolecule polymer has different physical properties under different pH values in the gastrointestinal tract, simply, the macromolecule polymer can be soluble in water or gradually swell in the acid environment of the stomach, and releases drugs; and similarly, different macromolecule polymers or composition thereof can be selected to release drugs in small intestines, large intestines or rectums, and the function of oriented drug administration is exerted.

Drug sustained-release pellet and method for preparing same

The invention discloses tamsulosin hydrochloride sustained-release pellets, which are prepared by coating medicament-containing blank pellets, wherein the blank pellets contain microcrystalline cellulose, soluble starch, lactose and croscarmellose sodium. Two layers of coating liquid are a Surelease sustained-release coating material and an enteric-coating material Kolicoat MAE 30DP respectively and the tamsulosin hydrochloride sustained-release pellets are capsules. The tamsulosin hydrochloride sustained-release pellets of the invention adopt the sustained-release coating material and the enteric-coating material to control the release of medicaments. The prepared tamsulosin hydrochloride sustained-release pellet capsules release less than 40 percent of medicaments in hydrochloric acid solution with a pH value of 1.2 in two hours and release 40 to 70 percent (about 60 percent) of medicaments in phosphate buffer solution with a pH value of 6.8 in three hours and over 70 percent (about 90 percent) of medicaments in five hours, so the prepared tamsulosin hydrochloride sustained-release pellet capsules meet the requirements of quality standards. The invention discloses a preparation method of the tamsulosin hydrochloride sustained-release pellets.

Tamsulosin hydrochloride sustained-release pellets and preparation method thereof

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Tamsulosin hydrochloride sustained-release pellets and preparation method thereof