Mingming Yang
University of Texas Southwestern Medical Center
12 Papers
8 Citations
Mingming Yang is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Medicine & Cancer research. The author has an hindex of 6, co-authored 9 publications.
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Papers
DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity.
Changzheng Lu,Junhong Guan,Steve Lu,Qihuang Jin,Benoit Rousseau,Tianshi Lu,Dennis Stephens,Hongyi Zhang,Jiankun Zhu,Mingming Yang,Zhenhua Ren,Yong Liang,Zhida Liu,Chuanhui Han,Longchao Liu,Xuezhi Cao,Anli Zhang,Jian Qiao,Kimberly Batten,Mingyi Chen,Diego H. Castrillon,Tao Wang,Bo Li,Luis A. Diaz,Guo Min Li,Yang Xin Fu +25 more
TL;DR: Using tumor models defective in the MMR gene Mlh1, it is shown that dMLH1 tumor cells accumulate cytosolic DNA and produce IFN-β in a cGAS-STING-dependent manner, which renders d MLH1 tumors slowly progressive and highly sensitive to checkpoint blockade.
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Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
Christina A. von Roemeling,Christina A. von Roemeling,Yifan Wang,Yaqing Qie,Yaqing Qie,Hengfeng Yuan,Hengfeng Yuan,Hai Zhao,Xiujie Liu,Zhaogang Yang,Mingming Yang,Weiye Deng,Katelyn A. Bruno,Charles Chan,Andrew S. Lee,Andrew S. Lee,Stephen S. Rosenfeld,Kyuson Yun,Aaron J. Johnson,Duane Mitchell,Wen Jiang,Betty Y.S. Kim +21 more
TL;DR: In glioblastoma mouse models, temozolomide improves the phagocytosis effect of CD47 blockade in APCs and results in the activation of adaptive anti-tumour responses, revealing a dynamic relationship between innate and adaptive immune regulation in tumours.
ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis
Yan Chen,Bo Zhang,Lei Bao,Lai Jin,Mingming Yang,Yan Peng,Ashwani Kumar,Jennifer E. Wang,Chenliang Wang,Xuan Zou,Chao Xing,Yingfei Wang,Weibo Luo +12 more
TL;DR: The findings uncover a primary epigenetic mechanism of HIF activation and HIF-mediated breast cancer progression, and discover a possible molecular target for the diagnosis and treatment of breast cancer.
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Cancer Immunotherapy based on Image-guided STING Activation by Nucleotide Nanocomplex-Decorated Ultrasound Microbubbles
Sina Khorsandi,Yifan Wang,Julien Santelli,Kristin Huntoon,Nhu Nguyen,Mingming Yang,DaeYong Lee,Yifei Lu,Ruoqi Gao,Betty Y.S. Kim,Caroline de Gracia Lux,Robert F. Mattrey,Wen Jiang,Jacques Lux +13 more
TL;DR: In this article , an ultrasound-guided cancer immunotherapy platform was developed using nanocomplexes composed of 2'3'-cyclic guanosine monophosphate-adenosine monoposphate (cGAMP) electrostatically bound to biocompatible branched cationic biopolymers that are conjugated onto antigen-targeting microbubbles (MBs).
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Immunocyte Membrane-Coated Nanoparticles for Cancer Immunotherapy
Gong Ping,Yifan Wang,Pengfei Zhang,Zhaogang Yang,Weiye Deng,Zhihong Sun,Mingming Yang,Xuefeng Li,Gongcheng Ma,Guanjun Deng,Shiyan Dong,Lintao Cai,Wen Jiang +12 more
TL;DR: In this article, the development of immunocyte membrane-coated nanoparticles in the immunotherapy of tumors is summarized, and the challenges to their large-scale preparation and application are reviewed.
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