Mingming Sun
Tongji University
15 Papers
1 Citations
Mingming Sun is an academic researcher from Tongji University. The author has contributed to research in topics: Inflammatory bowel disease & Tumor necrosis factor alpha. The author has an hindex of 10, co-authored 15 publications.
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Papers
miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-α in IBD
Chong He,Yan Shi,Ruijin Wu,Mingming Sun,Leilei Fang,Wei Wu,Wei Wu,Changqin Liu,Maochun Tang,Zhong Li,Ping Wang,Yingzi Cong,Zhanju Liu +12 more
TL;DR: A novel mechanism in which the elevated miR-301a in PBMC and inflamed mucosa of patients with IBD promotes Th17 cell differentiation through downregulation of SNIP1 is revealed and may serve as a novel therapeutic approach in the treatment of IBD.
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miR-10a inhibits dendritic cell activation and Th1/Th17 cell immune responses in IBD
Wei Wu,Wei Wu,Chong He,Chong He,Changqin Liu,Anthony T. Cao,Xiaochang Xue,Heather L. Evans-Marin,Mingming Sun,Leilei Fang,Suxia Yao,Irina V. Pinchuk,Don W. Powell,Zhanju Liu,Yingzi Cong +14 more
TL;DR: The data indicate that miR-10a is decreased in the inflamed mucosa of IBD and downregulates mucosal inflammatory response through inhibition of IL-12/IL-23p40 and NOD2 expression, and blockade of Th1/Th17 cell immune responses.
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Cyclosporine modulates neutrophil functions via the SIRT6-HIF-1α-glycolysis axis to alleviate severe ulcerative colitis.
Huiying Lu,Jian Lin,Chunjin Xu,Mingming Sun,Keqiang Zuo,Xiaoping Zhang,Mingsong Li,Hailiang Huang,Hailiang Huang,Zhong Li,Wei Wu,Bai-Sui Feng,Zhanju Liu,Zhanju Liu +13 more
TL;DR: In this paper, small interfering RNA and inhibitors were used to knock down Sirtuin 6 (SIRT6) in HL-60 cells and block expression of SIRT6, hypoxia-inducible factor 1α (HIF-1α), and pyruvate dehydrogenase lipoamide kinase isozyme 4 (PDK4) in neutrophils.
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Clinical significance of soluble immunoglobulins A and G and their coated bacteria in feces of patients with inflammatory bowel disease.
Ritian Lin,Hongwei Chen,Weigang Shu,Mingming Sun,Leilei Fang,Yanhong Shi,Zhi Pang,Wei Wu,Zhanju Liu +8 more
TL;DR: The percentage of IgA- and IgG-coated bacteria markedly increased in feces of IBD patients, especially in CD patients at the age of 17 to 40 years old, with terminal ileal lesions and perianal lesions, as well as from E2 UC patients, and was closely associated with disease activities.
MicroRNA-125a suppresses intestinal mucosal inflammation through targeting ETS-1 in patients with inflammatory bowel diseases.
Yadong Ge,Mingming Sun,Wei Wu,Caiyun Ma,Cui Zhang,Chong He,Junxiang Li,Yingzi Cong,Dekui Zhang,Zhanju Liu +9 more
TL;DR: The data suggest that miR-125a protects intestinal mucosa from inflammatory injury and that ETS-1 as its target participates in the pathogenesis of IBD.
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