Mingming Sun
University of Texas Medical Branch
17 Papers
3 Citations
Mingming Sun is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Gut flora & Biology. The author has an hindex of 10, co-authored 13 publications. Previous affiliations of Mingming Sun include Tongji University.
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Papers
Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases.
TL;DR: Recent progresses of SCFA in regulation of intestinal homeostasis as well as in pathogenesis of IBD are summarized.
Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
Mingming Sun,Mingming Sun,Wei Wu,Wei Wu,Liang Chen,Liang Chen,Wenjing Yang,Wenjing Yang,Xiangsheng Huang,Caiyun Ma,Feidi Chen,Yi Xiao,Ye Zhao,Chunyan Ma,Suxia Yao,Victor H. Carpio,Sara M. Dann,Qihong Zhao,Zhanju Liu,Yingzi Cong +19 more
TL;DR: G gut microbiota-derived short-chain fatty acids (SCFAs) promote microbiota antigen-specific Th1 cell IL-10 production, mediated by G-protein coupled receptors 43 (GPR43), to provide insight into how microbiota metabolites regulate Th1cell functions to maintain intestinal homeostasis.
GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3
Ye Zhao,Feidi Chen,Wei Wu,Mingming Sun,Anthony J. Bilotta,Suxia Yao,Yi Xiao,Yi Xiao,Xiangsheng Huang,Tonyia Eaves-Pyles,George Golovko,Yuriy Fofanov,Warren N. D'Souza,Qihong Zhao,Zhanju Liu,Yingzi Cong +15 more
TL;DR: The studies demonstrated that microbiota metabolites SCFA promoted IEC RegIIIγ and β-defensins in a GPR43-dependent manner, providing a novel pathway by which microbiota regulates IEC expression of AMP and intestinal homeostasis.
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Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43.
Wei Wu,Mingming Sun,Mingming Sun,Feidi Chen,Anthony T. Cao,Houpu Liu,Ye Zhao,Xiangsheng Huang,Yi Xiao,Suxia Yao,Qihong Zhao,Zhanju Liu,Yingzi Cong +12 more
TL;DR: It is reported here that microbiota metabolite short-chain fatty acid acetate promoted intestinal IgA responses, which was mediated by “metabolite-sensing” GPR43, which identified a new pathway by which microbiota promotes intestine IgA response through its metabolites.
384
Microbiota Metabolite Butyrate Differentially Regulates Th1 and Th17 Cells’ Differentiation and Function in Induction of Colitis
Liang Chen,Liang Chen,Mingming Sun,Mingming Sun,Wei Wu,Wei Wu,Wenjing Yang,Wenjing Yang,Xiangsheng Huang,Yi Xiao,Chunyan Ma,Leiqi Xu,Suxia Yao,Zhanju Liu,Yingzi Cong +14 more
TL;DR: Data indicate that butyrate controls the capacity of T cells in the induction of colitis by differentially regulating Th1 and Th17 cell differentiation and promoting IL-10 production, providing insights intobutyrate as a potential therapeutic for the treatment of inflammatory bowel disease.