Mingjun Shi
33 Papers
38 Citations
Mingjun Shi is an academic researcher. The author has contributed to research in topics: Downregulation and upregulation & Medicine. The author has an hindex of 10, co-authored 22 publications.
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Papers
Oxymatrine Inhibits Renal Tubular EMT Induced by High Glucose via Upregulation of SnoN and Inhibition of TGF-β1/Smad Signaling Pathway.
TL;DR: C cultured normal rat renal tubular epithelial cells in high glucose and high glucose plus OM showed that E-cadherin and SnoN expression in NRK52Es decreased significantly, but poly-ubiquitination of SnoN, TGF-β1, α-SMA, FN, Arkadia, p-Smad2 and p- Smad3 expression significantly increased due to high glucose stimulation, suggesting that OM could be a novel therapeutic for DN.
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy
Yuxia Zhou,Lu Liu,Bangming Jin,Yixuan Wu,Lifen Xu,Xuebing Chang,Laying Hu,Guifang Wang,Yali Huang,Lingyu Song,Ting Zhang,Yuanyuan Wang,Ying Xiao,Fan Zhang,Mingjun Shi,Lingling Liu,Tuan Lao Wang,Rui Yan,Bing Guo +18 more
TL;DR: In this paper , the Meteorin-like (Metrnl) gene product mediates lipid accumulation in the kidney and has therapeutic potential for diabetic kidney disease (DKD) and has been shown to be a stress-responsive regulator of kidney pathophysiology.
Regulation of PTEN/AKT/FAK pathways by PPARγ impacts on fibrosis in diabetic nephropathy.
TL;DR: The results showed that PPARγ regulated the expression of PTEN at a transcriptional level and further regulated EMT and TIF, and this dual activity could regulate the phosphorylation level of AKT and FAK and also affect FAK transcription.
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Suberoylanilide hydroxamic acid attenuates paraquat-induced pulmonary fibrosis by preventing Smad7 from deacetylation in rats.
Shanshan Rao,Xiangyan Zhang,Mingjun Shi,Ying Xiao,Yingying Zhang,Yuanyuan Wang,Chang-Zhi Zhang,Songjun Shao,Xin-Mei Liu,Bing Guo +9 more
TL;DR: In vitro study showed that SAHA suppressed TGF-β1-induced fibroblast differentiation into myofibroblasts, and exerted its antifibrotic effect through preventing Smad7 from deacetylation, most maybe by inhibiting T GF-β 1-induced HDAC1 activity.
BMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease
Wei Peng,Xingcheng Zhou,Tingting Xu,Yanwen Mao,Xiaohuan D. Zhang,Huiming Liu,Luqun Liang,Lingling Liu,Lirong Liu,Ying Xiao,Fan Zhang,Shuangbao Li,Mingjun Shi,Yuxia Zhou,Lei Tang,Yuanyuan Wang,Bing Guo +16 more
TL;DR: In this paper , the authors demonstrated that BMP-7 upregulated the expression of endogenous SnoN against renal TIF induced by TGF-β1 or hyperglycemia.