Hospitals played vital role in the maintenance and sustenance of human health. However, hospital activities generate high volume of toxic solid and liquid containing diverse inorganic, organic and microbial wastes released untreated into the ecosystem. The management of hospital wastewater in particular has been a major source of concern due to the presence of unregulated emerging micro-pollutants at concentrations in the range of ng/L to μg/L. These pollutants at low concentration exert different potential health effects on human and aquatic species. In this review, the formation, composition, properties and ecotoxicology effects of selected emerging micro-pollutants (Norfloxacin, Ofloxacin, Ciprofloxacin, Clofibric acid and Carbamazepine) at different concentrations in hospital wastewater were reviewed. The review also elucidates on detection and quantification of concentration of different emerging micropollutants in hospital wastewater by Spectrophotometry techniques, Gas Chromatography, Ion Chromatography, Gas Chromatography-Mass spectrometry, and High-Performance Liquid Chromatography. Furthermore, treatment of hospital wastewater through physical, biological, chemical, adsorption and advanced oxidation processes such as photocatalysis and photo-Fenton including their operational mechanism were provided. The chemistry and mechanism of degradation of the selected emerging micropollutants into several intermediates were reviewed. It was found that conventional wastewater treatment methods are not designed for effective removal of these unregulated pollutants in hospital wastewater because they exist as mixtures at very high concentrations and exerts different toxicological effects. The review also reveals that no single technology can effectively detoxify the wastewater, instead combination of methods such as (phototcatalytic/adsorption or photo-fenton/adsorption) was found most appropriate for hospital wastewater treatment. Finally, regular monitoring and determination of physicochemical and ecotoxicological parameters and treatment of hospital wastewater are recommended. • Formation, composition and properties of hospital wastewater were examined. • (Eco) toxicology effects of selected emerging micro-pollutants at low concentration in hospital were reviewed. • The usefulness of various techniques for the detection and quantification of concentration of different emerging micro-pollutants in hospital wastewater and their shortcoming were examined. • Hybrid treatment methods were found appropriate for the treatment of hospital wastewater. 

A review of emerging micro-pollutants in hospital wastewater: Environmental fate and remediation options

A photoelectrochemical aptasensor for the determination of bisphenol A based on the Cu (I) modified graphitic carbon nitride.

Histamine and Scombrotoxins.

One of the most advanced, promising, and commercially viable research issues in the world of hydrogel dressing is gaining functionality to achieve improved therapeutic impact or even intelligent wound repair. In addition to the merits of ordinary hydrogel dressings, functional hydrogel dressings can adjust their chemical/physical properties to satisfy different wound types, carry out the corresponding reactions to actively create a healing environment conducive to wound repair, and can also control drug release to provide a long-lasting benefit. Although a lot of in-depth research has been conducted over the last few decades, very few studies have been properly summarized. In order to give researchers a basic blueprint for designing functional hydrogel dressings and to motivate them to develop ever-more intelligent wound dressings, we summarized the development of functional hydrogel dressings in recent years, as well as the current situation and future trends, in light of their preparation mechanisms and functional effects.

/pdf/advances-in-functional-hydrogel-wound-dressings-a-review-2honl4q2.pdf

Advances in Functional Hydrogel Wound Dressings: A Review

Analysis of unknowns in recycled LDPE plastic by LC-Orbitrap Tribrid HRMS using MS3 with an intelligent data acquisition mode

Development of an analytical method for urocanic acid isomers in fish based on reactive extraction cleanup and chaotropic chromatography techniques.

Microsized β-chitin fibers were prepared, and PAAm /β-chitin composited hydrogels were synthesized by situ free radical polymerization. The morphology, mechanical properties, swelling ratio, transparency and drug release capabilities of the composited PAAm hydrogels were studied systematically. The results showed that the microsized β-chitin fibers were evenly dispersed in the PAAm hydrogels, and the tensile and compressive strength of PAAm hydrogels were increased by 2.1 folds and 4.4 folds respectively by adding with 15 phr microsized β-chitin fibers, while water absorbency and transparency of the hydrogels were decreased with higher microsized β-chitin fibers content. The drug release behaviors of diclofenac sodium in the hydrogel followed the Fickian diffusion mechanism with n value of 0.099 and 0.147 for PAAm hydrogels and PAAm/β-chitin composite hydrogels respectively, and the release time of 60 % drug were extended from 1 h to 5 h by the addition of 5 phr microsized β-chitin fibers. The results indicate that microsized β-chitin fibers can improve the mechanical properties and decrease the drug release rate of PAAm hydrogel, and the composited hydrogels may find potential applications in the field of transdermal drug delivery system. 

Poly(acrylamide) Hydrogel Composites With Microsized β-chitin Fiber and the Properties of Mechanical and Drug Release

Cellular drug response (concentration required for obtaining 50% of a maximum cellular effect, EC50) can be predicted by the intracellular bioavailability (Fic) and biochemical activity (half-maximal inhibitory concentration, IC50) of drugs. In an ideal model, the cellular negative log of EC50 (pEC50) equals the sum of log Fic and the negative log of IC50 (pIC50). Here, we measured Fic’s of remdesivir, favipiravir, and hydroxychloroquine in various cells and calculated their anti-SARS-CoV-2 EC50’s. The predicted EC50’s are close to the observed EC50’s in vitro. When the lung concentrations of antiviral drugs are higher than the predicted EC50’s in alveolar type 2 cells, the antiviral drugs inhibit virus replication in vivo, and vice versa. Overall, our results indicate that both in vitro and in vivo antiviral activities of drugs can be predicted by their intracellular bioavailability and biochemical activity without using virus. This virus-free strategy can help medicinal chemists and pharmacologists to screen antivirals during early drug discovery, especially for researchers who are not able to work in the high-level biosafety lab.

Predicting In Vitro and In Vivo Anti-SARS-CoV-2 Activities of Antivirals by Intracellular Bioavailability and Biochemical Activity

High-performance liquid chromatography (HPLC)-fluorescence method for determination of bisphenol A diglycidyl ether (BADGE) and its derivatives in canned foods.

Biodegradable GdPO4·H2O/PLGA microcarriers for stem cell delivery and non-invasive MRI translocation tracing

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Mingfeng He

Author Tools

Chat about Author