Ming Yao
Zhejiang University
8 Papers
70 Citations
Ming Yao is an academic researcher from Zhejiang University. The author has contributed to research in topics: Gene delivery & TLR4. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Ming Yao include Second Military Medical University.
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Papers
CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages
TL;DR: It is demonstrated that TLR 4, 9, and 3 ligands markedly induce intracellular calcium fluxes and activate CaMKII-alpha in macrophages, and in turn promotes both myeloid differentiating factor 88 and Toll/IL-1 receptor domain-containing adaptor protein-inducing IFN-beta-dependent inflammatory responses by directly activating TAK1 and IRF3.
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Late Endosome/Lysosome-Localized Rab7b Suppresses TLR9-Initiated Proinflammatory Cytokine and Type I IFN Production in Macrophages
TL;DR: The results suggest that the late endosome/lysosome-localized Rab7b can down-regulate TLR9-triggered proinflammatory cytokine and type I IFN production by impairingTLR9 signaling via promotion of TLR 9 degradation.
Scaffolding Adaptor Protein Gab1 Is Required for TLR3/4- and RIG-I–Mediated Production of Proinflammatory Cytokines and Type I IFN in Macrophages
TL;DR: It is demonstrated that Gab1 significantly enhances TLR4-, TLR3-, and RIG-I–triggered IL-6, IL-1β, and IFN-α/β production in macrophages and inhibits VSV replication and VSV infection-induced cell damage by inducing type I IFNs and IFn-inducible gene expression via PI3K/Akt pathway.
Systemic genetic transfer of p21WAF-1 and GM-CSF utilizing of a novel oligopeptide-based EGF receptor targeting polyplex.
TL;DR: The results demonstrated that combined administration of p21WAF−1 and GM-CSF could remarkably inhibit the growth of subcutaneously transplanted hepatoma Hepa cells, and significantly increase the survival rate of tumor-bearing mice.
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Enhanced antitumor effect of EGF R-targeted p21WAF-1 and GM-CSF gene transfer in the established murine hepatoma by peritumoral injection.
TL;DR: The data demonstrate that the GE7 system–mediated, EGF R–targeted cotransfer of p21WAF-1 and GM-CSF genes exhibit more potent antitumor effect by inducing tumor cell apoptosis and inflammatory responses.
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