Ming Ruan
Mayo Clinic
27 Papers
49 Citations
Ming Ruan is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Osteoclast & Osteoblast. The author has an hindex of 13, co-authored 16 publications.
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Papers
Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate
TL;DR: The findings indicate that osteoclasts may recruit osteoprogenitors to the site of bone remodeling through SIP and BMP6 and stimulate bone formation through increased activation of Wnt/BMP pathways.
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Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism.
Megan M. Weivoda,Megan M. Weivoda,Chee Kian Chew,Chee Kian Chew,David G. Monroe,Joshua N. Farr,Elizabeth J. Atkinson,Jennifer R. Geske,Brittany A. Eckhardt,Brianne S Thicke,Ming Ruan,Amanda J Tweed,Louise K. McCready,Robert A. Rizza,Aleksey V. Matveyenko,Moustapha Kassem,Moustapha Kassem,Thomas Levin Andersen,Thomas Levin Andersen,Adrian Vella,Matthew T. Drake,Bart L. Clarke,Merry Jo Oursler,Sundeep Khosla +23 more
TL;DR: Several coupling factors in humans are identified and osteoclast-derived DPP4 may be a factor coupling bone resorption to energy metabolism, as a potential link between bone remodeling and energy metabolism.
Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways
Patrick Quint,Ming Ruan,Larry Pederson,Moustapha Kassem,Moustapha Kassem,Jennifer J. Westendorf,Sundeep Khosla,Merry Jo Oursler +7 more
TL;DR: Osteoclasts produce sphingosine 1-phosphate (S1P), which stimulates mesenchymal (skeletal) stem cell migration by activating kinase signaling pathways, and data demonstrate that the chemokine S1P couples bone formation to bone resorption through activation of kinase signaled pathways.
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2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo
Muzaffer Cicek,Urszula T. Iwaniec,Michael J. Goblirsch,Anne M. Vrabel,Ming Ruan,Denis R. Clohisy,Russell R. Turner,Merry Jo Oursler +7 more
TL;DR: The data support the conclusion that 2ME(2) could be an important new therapy in the arsenal to fight metastatic breast cancer.
41
Transforming Growth Factor-β Coordinately Induces Suppressor of Cytokine Signaling 3 and Leukemia Inhibitory Factor to Suppress Osteoclast Apoptosis
TL;DR: Investigation of the mechanisms by which LIF promotes osteoclast survival revealed that LIF-induced expression of Bcl-X(L) and repressed B cl-2 interacting domain expression by activating MAPK kinase, AKT, and nuclear factor-kappaB pathways, leading to prolonged osteOClast survival.