The noble metal nanoparticle has been widely utilized as a plasmonic unit to enhance biosensors, by leveraging its electric and/or optical properties. Integrated with the "flexible" feature, it further enables opportunities in developing healthcare products in a conformal and adaptive fashion, such as wrist pulse tracers, body temperature trackers, blood glucose monitors, etc. In this work, we present a holistic review of the recent advance of flexible plasmonic biosensors for the healthcare sector. The technical spectrum broadly covers the design and selection of a flexible substrate, the process to integrate flexible and plasmonic units, the exploration of different types of flexible plasmonic biosensors to monitor human temperature, blood glucose, ions, gas, and motion indicators, as well as their applications for surface-enhanced Raman scattering (SERS) and colorimetric detections. Their fundamental working principles and structural innovations are scoped and summarized. The challenges and prospects are articulated regarding the critical importance for continued progress of flexible plasmonic biosensors to improve living quality.

Flexible Plasmonic Biosensors for Healthcare Monitoring: Progress and Prospects.

Gold nanorods etching as a powerful signaling process for plasmonic multicolorimetric chemo-/biosensors: Strategies and applications

A flexible electrochemical sensor for paracetamol based on porous honeycomb-like NiCo-MOF nanosheets

Highly Pure Gold Nanotriangles with almost 100% Yield for Surface-Enhanced Raman Scattering

A novel enhanced electrochemical sensor based on the peroxidase-like activity of Fe3O4@Au/MOF for the detection of p-aminophenol

p-Aminophenol (p-AP) is one of the common environmental pollutants with teratogenic effects, nephrotoxicity and genotoxicity In this study, a novel colorimetric method for quickly, sensitive and on-site detection of p-AP was developed based on target induced etching of AuNRs, which will generate colorful color changes Our investigation reveals that potassium iodate (KIO3) can be reduced by p-AP to generate iodine (I2), and I2 can etch CTAB stabilized AuNRs along the longitudinal direction As an emerging fascinating colorimetric material, LSPR extinction peak of AuNRs will shift to short wave direction with a color change from the initial tea red to brown, gray, dark green, cyan, blue, indigo, purple, purplish red and final pink Under the optimal conditions, our strategy is analytically specific and sensitive for the detection of p-AP from 05 μM to 20 μM by the naked eye, and a detection limit of 027 μM was achieved Meanwhile, this colorimetric method is used to detect p-AP in environmental water, paracetamol tablets and human urine Hence, this proposed strategy has the advantages of rapid semi-quantitative analysis of p-AP with naked eyes, simple operation and good application prospect

Semi-quantitative detection of p-Aminophenol in real samples with colorfully naked-eye assay

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Semi-quantitative detection of p-Aminophenol in real samples with colorfully naked-eye assay