Ming-Feng He
8 Papers
Ming-Feng He is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 5 publications.
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Papers
YWHAZ variation causes intellectual disability and global developmental delay with brain malformation
Rui-Ping Wan,Zhigang Liu,Xiao Fei Huang,Ping Kwan,Ya Ping Li,Xiao-Chong Qu,Xingguang Ye,Feng-Ying Chen,Da Wei Zhang,Ming-Feng He,Jie Wang,Yu-Ling Mao,Jingda Qiao +12 more
TL;DR: Clinical and experimental results consistently suggested that YWHAZ was a novel intellectual disability pathogenic gene and computational modeling showed that the binding energy was increased in the mutated protein combining with the ligand indicating that the c147A > T variation was a loss-of-function variant.
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ZFHX3 variants cause childhood partial epilepsy and infantile spasms with favourable outcomes.
Ming-Feng He,Li Hong Liu,Sheng Luo,Juan Wang,Jia-Jun Guo,Pengchao Wang,Qiongxiang Zhai,Su‐Li He,Dong-Fang Zou,Xiao-Rong Liu,Bing-Mei Li,Hai-Yan Ma,Jing-Da Qiao,Peng Zhou,Na He,Wei-Ping Liao +15 more
TL;DR: ZFHX3 variants cause childhood partial epilepsy and infantile spasms with favourable outcomes. ZFHX3 is a novel causative gene of childhood partial epilepsy and DEE. The patients achieved seizure-free after treatment without adrenocorticotropic-hormone/steroids.
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Coptisine Inhibits Influenza Virus Replication by Upregulating p21
Ming-Feng He,Jian-Hui Liang,Yanqiong Shen,Chao Zhang,Kuangyang Yang,Li-Chu Liu,Qian Xie,Chun Hu +7 more
TL;DR: In this paper , coptisine upregulated the p21 signaling pathway in MDCK cells, which was responsible for its antiviral effects, while leaving the MELK expression unchanged.
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ZFHX3 Associated with Partial Epilepsy/Spasms and Correlation between Outcome & Gene Expression Stage
Ming-Feng He,Li Hong Liu,Sheng Luo,Juan-Juan Wang,Jialing Guo,Peng-yu,Wang,Qiongxiang Zhai,S. L. He,Dong-Fang Zou,Xiao-Rong Liu,Li,Hai-yan Ma,Jingda Qiao,Peng Zhou,Na He,Yong-Hong Yi,Wei-Ping Liao +17 more
TL;DR: Zhang et al. as mentioned in this paper explored the relationship between ZFHX3 variants and epilepsy using whole-exome sequencing in patients with partial epilepsy without acquired causes and found that the association between the ZFHx3 gene and human disease was undefined.
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MED12 variants associated with X-linked recessive partial epilepsy without intellectual disability
Jie Yang,Zhigang Liu,Chunxing Liu,Jinghui Zhang,Yankai Jia,Qiongxiang Zhai,Ming-Feng He,Na He,Jingda Qiao +8 more
TL;DR: In this article , the association between MED12 variants and epilepsy was explored in a cohort of 349 unrelated cases with partial (focal) epilepsy without acquired causes, and the genotype-phenotype correlations of the variants were analyzed.
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