Min Yuan
Princeton University
8 Papers
Min Yuan is an academic researcher from Princeton University. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Min Yuan include University of Washington.
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Papers
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors
Xin Lu,Euphemia Mu,Yong Wei,Sabine Riethdorf,Qifeng Yang,Qifeng Yang,Min Yuan,Jun Yan,Yuling Hua,Benjamin Tiede,Xuemin Lu,Bruce G. Haffty,Klaus Pantel,Joan Massagué,Yibin Kang,Yibin Kang +15 more
TL;DR: A bone metastasis dormancy model is characterized to show that aberrant expression of vascular cell adhesion molecule 1 (VCAM-1), in part dependent on the activity of the NF-κB pathway, promotes the transition from indolent micrometastasis to overt metastasis.
504
Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy
Hanqiu Zheng,Yangjin Bae,Sabine Kasimir-Bauer,Rebecca Tang,Jin Chen,Guangwen Ren,Min Yuan,Mark Esposito,Wenyang Li,Yong Wei,Minhong Shen,Lanjing Zhang,Nikolai Tupitsyn,Klaus Pantel,Chadwick T. King,Jan Sun,Jodi Moriguchi,Helen Toni Jun,Angela Coxon,Brendan Lee,Yibin Kang,Yibin Kang +21 more
TL;DR: 15D11 dramatically sensitizes bone metastasis to chemotherapy, which induces Jagged1 expression in osteoblasts to provide a survival niche for cancer cells, establishing 15D11 as a potential therapeutic agent for the prevention or treatment ofBone metastasis.
153
MTDH-SND1 Interaction Is Crucial for Expansion and Activity of Tumor-Initiating Cells in Diverse Oncogene- and Carcinogen-Induced Mammary Tumors
Liling Wan,Xin Lu,Salina Yuan,Yong Wei,Feng Guo,Minhong Shen,Min Yuan,Rumela Chakrabarti,Yuling Hua,Heath A. Smith,Mario Andres Blanco,Marina Chekmareva,Hao Wu,Roderick T. Bronson,Bruce G. Haffty,Yongna Xing,Yibin Kang,Yibin Kang +17 more
TL;DR: It is demonstrated that Metadherin gene plays a critical role in mammary tumorigenesis by regulating oncogene-induced expansion and activities of tumor-initiating cells (TICs), whereas it is largely dispensable for normal development.
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In Vivo Dynamics and Distinct Functions of Hypoxia in Primary Tumor Growth and Organotropic Metastasis of Breast Cancer
Xin Lu,Carol H. Yan,Carol H. Yan,Min Yuan,Yong Wei,Guohong Hu,Guohong Hu,Yibin Kang,Yibin Kang +8 more
TL;DR: In this paper, a comparative analysis of the potentially distinct functions of hypoxia in primary tumor growth and organ-specific metastasis has not been reported, however, a study showed distinct hypoxIA kinetics in tumors generated by the MDA-MB-231 breast cancer sublines with characteristically different primary tumor tumor growth rates and organotropic metastasis potentials.
91
Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis.
Minhong Shen,Shanshan Xie,Michelle Rowicki,Sven Michel,Yong Wei,Xiang Hang,Liling Wan,Xin Lu,Min Yuan,John F. Jin,Frank Jaschinski,Tianhua Zhou,Tianhua Zhou,Richard Klar,Yibin Kang,Yibin Kang +15 more
TL;DR: It is found that metadherin promotes cancer progression by facilitating Wnt activation and by inducing cytotoxic T-cell exhaustion, respectively, and locked nucleic acid-modified (LNA) MTDH antisense oligonucleotides (ASO) that effectively and specifically suppress MTDH expression in vitro and in vivo are developed.
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