Min Yu
Fudan University
26 Papers
98 Citations
Min Yu is an academic researcher from Fudan University. The author has contributed to research in topics: C-Met & Pichia pastoris. The author has an hindex of 9, co-authored 25 publications.
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Papers
Thrombin is a therapeutic target for non-small-cell lung cancer to inhibit vasculogenic mimicry formation.
Bing Zhao,Mengfang Wu,Zhihuang Hu,Yixin Ma,Wang Qi,Yanling Zhang,Yaran Li,Min Yu,Huijie Wang,Wei Mo,Wei Mo +10 more
TL;DR: This research revealed that thrombin induced VM formation via PAR-1-mediated NF-κB signaling cascades and illustrated that VM might be a target of r-hirudin and DTIP to suppress tumor progression.
A novel bispecific c-MET/PD-1 antibody with therapeutic potential in solid cancer.
TL;DR: A potential bispecific drug is identified that can effectively target c-MET and PD-1 for the treatment of human solid cancers and markedly inhibits the growth of subcutaneously implanted tumors and chronic inflammation.
Dual-function chimeric antigen receptor T cells targeting c-Met and PD-1 exhibit potent anti-tumor efficacy in solid tumors
Xingxing Yuan,Zujun Sun,Zujun Sun,Qingyun Yuan,Weihua Hou,Qiaoyan Liang,Yuxiong Wang,Wei Mo,Huijie Wang,Min Yu +9 more
TL;DR: It is confirmed that the novel dual-function CAR-T cells exhibit stronger anti-tumor activity against solid tumors than traditional single-target CAR-t cells and present a new approach that enhance the activity of CAR- T cells in solid tumors.
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Structural basis of RGD-hirudin binding to thrombin: Tyr3 and five C-terminal residues are crucial for inhibiting thrombin activity.
Yinong Huang,Yanling Zhang,Bing Zhao,Qiping Xu,Xiushi Zhou,Houyan Song,Houyan Song,Min Yu,Wei Mo +8 more
TL;DR: These findings contribute to a novel understanding of the interaction between RGD-hirudin and thrombin.
A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer.
Bing Zhao,Mengfang Wu,Zhihuang Hu,Tianfa Wang,Jin Chao Yu,Yixin Ma,Qi Wang,Yanling Zhang,Di Chen,Tianyu Li,Yaran Li,Min Yu,Huijie Wang,Wei Mo +13 more
TL;DR: In this paper, the effects of r-hirudin and direct thrombin inhibitor peptide (DTIP) on cancer progression were evaluated and the therapeutic effect of the combination of DTIP and chemotherapy was determined.
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