Min-Young Lee
Samsung Medical Center
75 Papers
188 Citations
Min-Young Lee is an academic researcher from Samsung Medical Center. The author has contributed to research in topics: Medicine & Conjugate. The author has an hindex of 19, co-authored 75 publications. Previous affiliations of Min-Young Lee include The Chinese University of Hong Kong & Sungkyunkwan University.
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Papers
Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives.
Eun Ju Oh,Kitae Park,Ki Su Kim,Jiseok Kim,Jeong-A Yang,Ji-Hyun Kong,Min-Young Lee,Allan S. Hoffman,Sei Kwang Hahn +8 more
TL;DR: A peer overview on novel HA derivatives and the latest advances in HA-based drug delivery systems of various biopharmaceuticals for further clinical development is given.
548
Nanographene Oxide–Hyaluronic Acid Conjugate for Photothermal Ablation Therapy of Skin Cancer
Ho Sang Jung,Won Ho Kong,Dong Kyung Sung,Min-Young Lee,Songeun Beack,Do Hee Keum,Ki Su Kim,Seok Hyun Yun,Sei Kwang Hahn,Sei Kwang Hahn +9 more
TL;DR: A nanographene oxide-HA conjugate (NGO-HA) was synthesized for photothermal ablation therapy of melanoma skin cancer using a near-infrared (NIR) laser and resulted in complete ablation of tumor tissues with no recurrence of tumorigenesis.
Hyaluronate–Gold Nanoparticle/Tocilizumab Complex for the Treatment of Rheumatoid Arthritis
Hwiwon Lee,Min-Young Lee,Suk Ho Bhang,Byung-Soo Kim,Yun Seop Kim,Ji Hyeon Ju,Ki Su Kim,Sei Kwang Hahn +7 more
TL;DR: The therapeutic effect of HA-AuNP/TCZ complex on RA was confirmed in collagen-induced arthritis (CIA) model mice by ELISA, histological, and Western blot analyses.
198
Hyaluronic Acid–Gold Nanoparticle/Interferon α Complex for Targeted Treatment of Hepatitis C Virus Infection
Min-Young Lee,Yang Jeong A,Ho Sang Jung,Songeun Beack,Jung Eun Choi,Wonhee Hur,Heebeom Koo,Kwangmeyung Kim,Seung Kew Yoon,Sei Kwang Hahn +9 more
TL;DR: A target-specific long-acting delivery system of IFNα was successfully developed using the hybrid materials of AuNP and hyaluronic acid, which significantly enhanced the expression of 2',5'-oligoadenylate synthetase 1 (OAS1) for innate immune responses to viral infection in the liver tissue, which was much higher than those by IFN α, PEG-Intron, and AuNP/IFNα complex.
167
Target-Specific Gene Silencing of Layer-by-Layer Assembled Gold–Cysteamine/siRNA/PEI/HA Nanocomplex
TL;DR: A cysteamine modified gold nanoparticles/siRNA/PEI/HA complex was successfully developed using a layer-by-layer method for target-specific intracellular delivery of siRNA by HA receptor mediated endocytosis and resulted in a significantly reduced ApoB mRNA level in the liver tissue.
153