24 Papers
36 Citations
Min Lu is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 11, co-authored 16 publications. Previous affiliations of Min Lu include University of Oxford & Anhui Medical University.
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Papers
Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.
Shuo Chen,Jiale Wu,Ying Liang,Yigang Tang,Huaxin Song,Li-Li Wu,Yang-Fei Xing,Ni Yan,Yuntong Li,Zhengyuan Wang,Shu-Jun Xiao,Xin Lu,Sai-Juan Chen,Min Lu +13 more
TL;DR: Arsenic trioxide (ATO) has been shown to stabilize the DNA-binding loop-sheet-helix motif alongside the overall β-sandwich fold, endowing p53 mutants with thermostability and transcriptional activity as discussed by the authors.
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Restoring the tumour suppressive function of p53 as a parallel strategy in melanoma therapy
Min Lu,Paul D. Miller,Xin Lu +2 more
TL;DR: Targeted therapy and concurrent reactivation of p53 may be a fertile ground to achieve synergistic killing of the 50% of cancer cells that express structurally wild type p53.
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Diverse rescue potencies of p53 mutations to ATO are predetermined by intrinsic mutational properties
Huaxin Song,Jiale Wu,Yigang Tang,Yuting Dai,Xinrong Xiang,Ya Li,Lili Wu,Ying Liang,Yangfei Xing,Ni Yan,Yuntong Li,Zhengyuan Wang,Shujun Xiao,Jiabing Li,Derun Zheng,Xin-Jie Chen,Hai-Jun Fang,Chenjing Ye,Yuting Ma,Yu Wu,Wen Wu,Junming Li,Su-Jiang Zhang,Min Lu +23 more
TL;DR: Song et al. as mentioned in this paper evaluated 800 common p53 mutants for their rescue potencies by the representative generic rescue compound arsenic trioxide (ATO) in terms of transactivation activity, cell growth inhibition, and mouse tumor-suppressive activities.
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iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.
Sheng-hong Chen,Jun Wu,Shan Zhong,Yin Li,P Zhang,Jianhui Ma,Jingshan Ren,Yun Tan,Yunhao Wang,Kin Fai Au,Christian Siebold,Gareth L. Bond,Zuojia Chen,Min Lu,E Y Jones,Xin Lu +15 more
TL;DR: This study addresses the mechanism by which iASPP, a p53 partner, influences p53 target gene selection and identifies sequence signatures enriched in genomic p53-binding sites modulated by the transcription cofactor i ASPP.
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