Min Chen
National University of Singapore
9 Papers
3 Citations
Min Chen is an academic researcher from National University of Singapore. The author has contributed to research in topics: Preimplantation genetic diagnosis & Microsatellite. The author has an hindex of 5, co-authored 8 publications. Previous affiliations of Min Chen include University Health System.
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Papers
Identification of microsatellite markers <1 Mb from the FMR1 CGG repeat and development of a single-tube tetradecaplex PCR panel of highly polymorphic markers for preimplantation genetic diagnosis of fragile X syndrome
TL;DR: The tetradecaplex marker assay can be performed directly on single cells or after whole-genome amplification, thus supporting its use in FXS PGD either as a standalone linkage-based assay or as a complement to FMR1 mutation detection.
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Rapid and reliable preimplantation genetic diagnosis of common hemoglobin Bart's hydrops fetalis syndrome and hemoglobin H disease determinants using an enhanced single-tube decaplex polymerase chain reaction assay.
Min Chen,Min Chen,Seong Feei Loh,Su Ling Yu,Suresh Nair,Heng Hao Tan,Sadhana Nadarajah,P.C. Wong,Soon Chye Ng,Ethiraj B. Prasath,Arnold S.C. Tan,Arnold S.C. Tan,Felicia S.H. Cheah,Eugene E. L. Saw,Samuel S. Chong,Samuel S. Chong +15 more
TL;DR: Vaccination with WT1 protein induces a significant cytotoxic response and a potent antibody response which may allow to overcome some of the limits associated with peptide vaccination including the restriction of the HLA typing of the patient and the prevalent T CD8 response.
4
Hereditary Spherocytosis Caused by a Novel Compound Heterozygous Mutation of SPTA1 and Autoimmune Hepatitis in a Pediatric Patient
Yuanhua Lin,Yan-yun Chen,Lin Liao,Yangyang Wu,Min Chen,Faquan Lin +5 more
TL;DR: In this paper , the authors examined the genetic and clinical features of a seven-year-old girl with yellow sclerae and abnormalities in liver function test results and found that the concurrent disorder may exist if a single autoimmune hepatopathy cannot explain laboratory findings.
Single‐tube nonaplex microsatellite PCR panel for preimplantation genetic diagnosis of Hb Bart's hydrops fetalis syndrome
Min Chen,Jerry Kok Yen Chan,Sadhana Nadarajah,Arnold S.C. Tan,Arnold S.C. Tan,Melinda L. H. Chan,Joyce Mathew,Eugene E. L. Saw,Cheryl Lim,Wendy Wong,Felicia S.H. Cheah,Hai-Yang Law,Hai-Yang Law,P.C. Wong,Samuel S. Chong,Samuel S. Chong +15 more
TL;DR: To develop a single‐tube multi‐marker assay for improved preimplantation genetic diagnosis (PGD) of deletional and/or non‐deletional Hb Bart's hydrops fetalis syndrome, providing haplotype confirmation of deletion status, and maximization of linkage informativity.
FMR1 CGG repeat expansion mutation detection and linked haplotype analysis for reliable and accurate preimplantation genetic diagnosis of fragile X syndrome.
Indhu-Shree Rajan-Babu,Mulias Lian,Felicia S.H. Cheah,Min Chen,Arnold S.C. Tan,Ethiraj B. Prasath,Seong Feei Loh,Samuel S. Chong +7 more
TL;DR: FMR1 TP-PCR reliably detects presence of expansion mutations and obviates reliance on informative normal alleles for determining expansion status in female embryos, and together with multi-marker haplotyping and gender determination, misdiagnosis and diagnostic ambiguity due to allele dropout is minimised, and couple-specific assay customisation can be avoided.