Mikiyasu Shirai
Monash University, Clayton campus
70 Papers
362 Citations
Mikiyasu Shirai is an academic researcher from Monash University, Clayton campus. The author has contributed to research in topics: Medicine & Vasodilation. The author has an hindex of 20, co-authored 70 publications. Previous affiliations of Mikiyasu Shirai include International University, Cambodia & Osaka University.
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Papers
Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension
Takahiro Hashimoto-Kataoka,Naoki Hosen,Takashi Sonobe,Yoh Arita,Taku Yasui,Takeshi Masaki,Masato Minami,Tadakatsu Inagaki,Shigeru Miyagawa,Yoshiki Sawa,Masaaki Murakami,Atsushi Kumanogoh,Keiko Yamauchi-Takihara,Meinoshin Okumura,Tadamitsu Kishimoto,Issei Komuro,Mikiyasu Shirai,Yasushi Sakata,Yoshikazu Nakaoka +18 more
TL;DR: It is suggested that IL-21 promotes PAH in association with M2 macrophage polarization, downstream of IL-6-signaling, through the polarization of primary alveolar macrophages toward the M2 phenotype.
226
Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice.
Hikari Takeshita,Koichi Yamamoto,Satoko Nozato,Tadakatsu Inagaki,Hirotsugu Tsuchimochi,Mikiyasu Shirai,Ryohei Yamamoto,Yuki Imaizumi,Kazuhiro Hongyo,Serina Yokoyama,Masao Takeda,Ryosuke Oguro,Yoichi Takami,Norihisa Itoh,Yasushi Takeya,Ken Sugimoto,So-ichiro Fukada,Hiromi Rakugi +17 more
TL;DR: The modified forelimb grip strength test, with its improved validity and reliability may be an ideal substitute for the conventional method in detecting skeletal muscle dysfunction in young male dystrophic mice.
Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice
Hikari Takeshita,Koichi Yamamoto,Satoko Nozato,Masao Takeda,So-ichiro Fukada,Tadakatsu Inagaki,Hirotsugu Tsuchimochi,Mikiyasu Shirai,Yoichi Nozato,Taku Fujimoto,Yuki Imaizumi,Serina Yokoyama,Motonori Nagasawa,Go Hamano,Kazuhiro Hongyo,Tatsuo Kawai,Hiroko Hanasaki-Yamamoto,Shuko Takeda,Toshimasa Takahashi,Hiroshi Akasaka,Norihisa Itoh,Yoichi Takami,Yasushi Takeya,Ken Sugimoto,Hironori Nakagami,Hiromi Rakugi +25 more
TL;DR: This work investigated whether deletion of ACE2 alters the development of muscle weakness by aging and whether angiotensin 1‐7 reverses muscle weakness in older mice.
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Acute Rho-kinase inhibition improves coronary dysfunction in vivo , in the early diabetic microcirculation
James T. Pearson,Mathew J. Jenkins,Mathew J. Jenkins,Amanda J. Edgley,Amanda J. Edgley,Takashi Sonobe,Mandar S. Joshi,Mark T. Waddingham,Mark T. Waddingham,Yutaka Fujii,Daryl O. Schwenke,Hirotsugu Tsuchimochi,Misa Yoshimoto,Keiji Umetani,Darren J. Kelly,Mikiyasu Shirai +15 more
TL;DR: In this article, an increase in RhoA/Rho-kinase activity plays a role in the deterioration of coronary vascular function in early stage diabetes, and the authors aimed to ascertain whether an increase of ROCK activity played a role.
Detection of endogenous acetylcholine release during brief ischemia in the rabbit ventricle: a possible trigger for ischemic preconditioning.
Toru Kawada,Tsuyoshi Akiyama,Shuji Shimizu,Atsunori Kamiya,Kazunori Uemura,Meihua Li,Mikiyasu Shirai,Masaru Sugimachi +7 more
TL;DR: Acute ischemia significantly increased the ACh levels in the rabbit left ventricle, which appeared to exceed the vagal stimulation-induced ACh release, suggesting that endogenous A choline release can be a trigger for ischemic preconditioning.
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