Mikhail P. Kirpichnikov
Moscow State University
364 Papers
1.3K Citations
Mikhail P. Kirpichnikov is an academic researcher from Moscow State University. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 34, co-authored 318 publications. Previous affiliations of Mikhail P. Kirpichnikov include Rutgers University & Russian Academy of Sciences.
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Papers
Crystal structure of PMGL2 esterase from the hormone-sensitive lipase family with GCSAG motif around the catalytic serine.
Konstantin M. Boyko,Marya V. Kryukova,Lada E. Petrovskaya,Alena Yu. Nikolaeva,D. A. Korzhenevsky,K. A. Novototskaya-Vlasova,Elizaveta Rivkina,Dmitry A. Dolgikh,Dmitry A. Dolgikh,Mikhail P. Kirpichnikov,Mikhail P. Kirpichnikov,Vladimir Popov,Vladimir Popov +12 more
TL;DR: The 3D structure of PMGL2, which belongs to the hormone-sensitive lipase (HSL) family and contains a new variant of the active site motif, GCSAG, was determined which demonstrated that PM GL2 and structurally characterized members of the GTSAG motif subfamily possess a common dimerization interface that significantly differs from that ofMembers of the GDSAG subfamily of known structure.
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Models of Head and Neck Squamous Cell Carcinoma Using Bioengineering Approaches.
Anton P. Bonartsev,Bo Lei,Margarita S. Kholina,Ksenia A. Menshikh,Dmitriy S. Svyatoslavov,Svetlana Samoylova,Mikhail Y. Sinelnikov,V. V. Voinova,Konstantin V. Shaitan,Mikhail P. Kirpichnikov,Igor V. Reshetov +10 more
TL;DR: The use of bioengineering methods and approaches is extremely promising for the development of experimental models of cancer, especially head and neck squamous cell carcinomas (HNSCC) that are characterized by early metastasis and rapid progression as mentioned in this paper .
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Inhibiting the pro-tumor and transcription factor FACT: Mechanisms
N. V. Maluchenko,Han-Wen Chang,M. T. Kozinova,M. E. Valieva,N. S. Gerasimova,N. S. Gerasimova,A. V. Kitashov,Mikhail P. Kirpichnikov,Pavel Georgiev,Vasily M. Studitsky,Vasily M. Studitsky,Vasily M. Studitsky +11 more
TL;DR: The data support the prospective use of FACT inhibitors as new anticancer drugs with multiple effects on cell metabolism, and support the development of new compounds capable of eliminating both rapidly proliferating tumor cells and standard treatment-resistant CSCs.
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The role of individual lysine residues of horse cytochrome c in the formation of reactive complexes with components of the respiratory chain
T. Yu. Pepelina,Rita V. Chertkova,Dmitry A. Dolgikh,Dmitry A. Dolgikh,Mikhail P. Kirpichnikov,Mikhail P. Kirpichnikov +5 more
TL;DR: The lysine residues in positions 8, 27, 72, 86, and 87 were shown to be the main contribution to the formation of a reactive complex with ubiquinol:cytochrome c reductase of the respiratory chain, whereas the lysins in positions 13, 79, 86 and 87were predominantly responsible for the formation for a complex with cy tochrome c oxidase.
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Multiple Mutations in the Non-Ordered Red Ω-Loop Enhance the Membrane-Permeabilizing and Peroxidase-like Activity of Cytochrome c
Rita V. Chertkova,Alexander M. Firsov,Nadezda A. Brazhe,Evelina I. Nikelshparg,Zhanna V. Bochkova,Tatyana V. Bryantseva,Marina A. Semenova,A. A. Baizhumanov,Elena A. Kotova,Mikhail P. Kirpichnikov,Georgy V. Maksimov,Yuri N. Antonenko,Dmitry A. Dolgikh +12 more
TL;DR: It is shown that both substitutions of Lys residues from the universal binding site for oppositely charged Glu residues and mutations leading to a decrease in the conformational mobility of the red Ω-loop did not affect the ability of cytochrome c to bind to cardiolipin.