Mike Relac
European Bioinformatics Institute
3 Papers
Mike Relac is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Gene & Eye development. The author has an hindex of 2, co-authored 2 publications.
Chat about Author
Papers
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium
Terrence F. Meehan,Nathalie Conte,David B. West,Julius O.B. Jacobsen,Jeremy Mason,Jonathan Warren,Chao-Kung Chen,Ilinca Tudose,Mike Relac,Peter Matthews,Natasha A. Karp,Luis Santos,Tanja Fiegel,Natalie Ring,Henrik Westerberg,Simon Greenaway,Duncan Sneddon,Hugh P. Morgan,Gemma F. Codner,Michelle Stewart,James M. Brown,Neil R. Horner,Melissa A. Haendel,Nicole L. Washington,Christopher J. Mungall,Corey L. Reynolds,Juan Gallegos,Valerie Gailus-Durner,Tania Sorg,Guillaume Pavlovic,Lynette Bower,Mark W. Moore,Iva Morse,Xiang Gao,Glauco P. Tocchini-Valentini,Yuichi Obata,Soo Young Cho,Je Kyung Seong,John R. Seavitt,Arthur L. Beaudet,Mary E. Dickinson,Yann Herault,Wolfgang Wurst,Martin Hrabé de Angelis,Kevin C K Lloyd,Ann M. Flenniken,Lauryl M. J. Nutter,Susan Newbigging,Colin McKerlie,Monica J. Justice,Stephen A. Murray,Karen L. Svenson,Robert E. Braun,Jacqueline K. White,Allan Bradley,Paul Flicek,Sara Wells,William C. Skarnes,David J. Adams,Helen Parkinson,Ann-Marie Mallon,Stephen D.M. Brown,Damian Smedley +62 more
TL;DR: Analyzing the first 3,328 genes identified models for 360 diseases, including the first models, to the knowledge, for type C Bernard–Soulier, Bardet–Biedl-5 and Gordon Holmes syndromes, and 90% of phenotype annotations were novel, providing functional evidence for 1,092 genes and candidates in genetically uncharacterized diseases.
Genome-wide screening reveals the genetic basis of mammalian embryonic eye development
Justin Chee,Louise Lanoue,Dave Clary,Kendall Higgins,Lynette Bower,Ann M. Flenniken,Ruolin Guo,David J. Adams,Fatima Bosch,Robert Braun,Steve D.M. Brown,H. J. Chin,Mary E. Dickinson,Chih-Wei Hsu,Michael Dobbie,Xiang Gao,Sanjeev Galande,Anne Grobler,Jason D. Heaney,Yann Herault,Martin Hrabé de Angelis,Fabio Mammano,Lauryl M. J. Nutter,Helen Parkinson,Chuan Qin,Toshihiko Shiroishi,Radislav Sedlacek,Je Kyung Seong,Ying Xu,Cheryl L. Ackert-Bicknell,Douglas J. Adams,Anne T. Adoum,Juan Antonio Aguilar-Pimentel,Uchechukwu Akoma,Dalila Ali-Hadji,Oana V. Amarie,Philippe André,Aurelie Auburtin,Chaouki Bam’Hamed,Johannes Beckers,Joachim Beig,Zorana Berberovic,Alexandr Bezginov,Marie-Christine Birling,Katharina Boroviak,Joanna Bottomley,Antje Bürger,Dirk H. Busch,Natalie C. Butterfield,Pilar Cacheiro,Julia Calzada-Wack,Emma L. Cambridge,Susan Camilleri,Marie-France Champy,Heather Cater,Philippe Charles,Elissa J. Chesler,Yi-Li Cho,Audrey E. Christiansen,Valentina Cipriani,Nicola Cockle,Gemma F. Codner,Amie Creighton,Maribelle Cruz,Katharine F. Curry,Abigail J. D’Souza,Ozge Danisment,Daniel J. Delbarre,Hannah F. Dewhurst,Brendan Doe,Alex Dorr,Florian Giesert,Graham Duddy,Kyle Duffin,Amal El Amri,Hillary Elrick,Mohammad Eskandarian,Martin Fray,Anthony David Frost,Helmut Fuchs,Valerie Gailus-Durner,K. K. Gampe,M Ganguly,David Gannon,Lillian Garrett,Marina Gertsenstein,Diane Gleeson,Leslie P. Goodwin,Jochen Graw,Kristin N Grimsrud,Hamed Haselimashhadi,Liane Hobson,Andreas Hörlein,Sabine M. Hölter,Seung-Hyun Hong,Neil R. Horner,Amanda G. Trainor,Ziyue Huang,Coleen Kane,Yulia Katsman,Lance C. Keith,Lois Kelsey,Janet Kenyon,Ruairidh King,Piia Keskivali-Bond,Andrea Kirton,Tanja Klein-Rodewald,Thomas Klopstock,Davide Komla-Ebri,Tomasz Konopka,R Kühn,Fiona Kussy,David T Lafont,Qing Lan,Denise G. Lanza,Valerie Laurin,Elise le Marchand,Sophie Leblanc,Victoria D. Leitch,Christopher J. Lelliott,Christoph Lengger,Lauri G. Lintott,John G. Logan,Isabel Lorenzo,Ann-Marie Mallon,Naila S. Mannan,Susan Marschall,Melissa L. McElwee,Matthew Mckay,Robbie S. B. McLaren-Jones,Jeremy Mason,Terrence F. Meehan,David Miller,Michayla A Moore,Violeta Muñoz-Fuentes,Stephen A. Murray,Dong Thi Nguyen-Bresinsky,Oskar Oritz,Panos Pandis,A. Parlog,Amit N. Patel,Guillaume Pavlovic,Monica Pereira,Kevin A. Peterson,Vivek M. Philip,Andrea S. Pollard,Jan Prochazka,Dawei Qu,Ayexa Ramirez,Sean Rangarajan,Tara L. Rasmussen,Birgit Rathkolb,Mike Relac,Kyle Roberton,W. Roper,Stéphane Rousseau,David W. Rowe,Jan Rozman,Jennifer L Ryan,Edward Ryder,Luis Santos,Adrian Sanz-Moreno,Joel Schick,Zachary Seavey,John R. Seavitt,Claudia Seisenberger,Mohammed Selloum,Xueyuan Shang,Dong-Guk Shin,Michelle Simon,Gillian T. Sleep,Damian Smedley,Tania Sorg,Penny C. Sparkes,Nadine Spielmann,Ralph Steinkamp,Michelle Stewart,Claudia Stoeger,Ewan Straiton,Karen L. Svenson,H. K. Swash,Lydia Teboul,Sandra Tondat,Irina Treise,Catherine Tudor,Rachel Urban,Valerie E. Vancollie,Laurent Vasseur,Igor Vukobradovic,Hannah Wardle-Jones,Jonathan Warren,Marie Wattenhofer-Donzé,Sara Wells,Jacqueline K. White,Jean-Paul Wiegand,Amelia M Willett,Catherine Witmeyer,Eckhard Wolf,Leeyean Wong,Joshua A Wood,Wolfgang Wurst,Catherine Xu,Annemarie Zimprich,Brian P. Brooks,Colin McKerlie,Kck Lloyd,Henrik Westerberg,Ala Moshiri +207 more
TL;DR: The authors identified novel genes and pathways required for early eye development through systematic forward screening of the mammalian genome, and used the International Mouse Phenotyping Consortium (IMPC) database (data release 17.0, August 01, 2022) to identify 74 unique knockout lines (genes) with genetically associated eye defects in mouse embryos.
A mouse informatics platform for phenotypic and translational discovery.
Natalie Ring,Terrence F. Meehan,Andrew Blake,James M. Brown,Chao-Kung Chen,Nathalie Conte,Armida Di Fenza,Tanja Fiegel,Neil R. Horner,Julius O.B. Jacobsen,Natasha A. Karp,Thomas N. Lawson,Jeremy Mason,Peter Matthews,Hugh Morgan,Mike Relac,Luis Santos,Damian Smedley,Duncan Sneddon,Alice Pengelly,Ilinca Tudose,Jonathan Warren,Henrik Westerberg,Gagarine Yaikhom,Helen Parkinson,Ann-Marie Mallon +25 more
TL;DR: A robust and highly structured informatics platform has been developed to systematically collate, analyse and disseminate the data produced by the IMPC, providing the world’s first functional catalogue of a mammalian genome by characterising a knockout mouse strain for every gene.