Mikael Simons

TL;DR: In this article , Scanlon et al. identify the mechanism by which diurnal rhythmicity in cardiac disease is disturbed and suggest a target for therapeutic intervention, by disabling macrophages in the superior cervical ganglia.

TL;DR: This method developed a method that links spatially-resolved gene expression of single cells with their ultrastructural morphology by integrating multiplexed error-robust fluorescence in situ hybridization and large area volume electron microscopy on adjacent tissue sections to offer an integrative view of the spatial, ultrastructureural, and transcriptional reorganization of single Cells after demyelinating brain injury.

TL;DR: It is demonstrated that CD8+ T cell-driven axonal damage is less likely to progress towards degeneration when axons are efficiently demyelinated by activated microglia and cytotoxic T cell effector molecules induce cytoskeletal alterations within myelinating glia.

TL;DR: This work applied MERFISH spatial transcriptomics with large area volume electron microscopy to characterize the damage-associated microglial identities in mouse brain, allowing us, for the first time, to link the morphology of foamy microglia and interferon-responsemicroglia with their transcriptional signatures.