Mika Virtala
University of California, Los Angeles
6 Papers
221 Citations
Mika Virtala is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Salmonella & Salmonella enteritidis. The author has an hindex of 5, co-authored 6 publications.
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Papers
HLA‐B27 modulates intracellular survival of Salmonella enteritidis in human monocytic cells
TL;DR: It is demonstrated that the expression of the HLA‐B27 antigen does not influence the uptake of S. enteritidis into U937 cells in vitro, and Interestingly, HLA•B27 remarkably impairs the elimination of S.'s enter itidis within the Hla‐B 27 transfected U9 37 cells.
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Salmonella-triggered reactive arthritis: use of polymerase chain reaction, immunocytochemical staining, and gas chromatography-mass spectrometry in the detection of bacterial components from synovial fluid.
S Nikkari,K. Rantakokko,P. Ekman,Timo Möttönen,Marjatta Leirisalo-Repo,Mika Virtala,L Lehtonen,Jari Jalava,P Kotilainen,Kaisa Granfors,P Toivanen +10 more
TL;DR: Findings indicate the presence of bacterial degradation products, but not bacterial DNA, in the inflamed joints of patients with Salmonella-triggered reactive arthritis.
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HLA-B27 modulates the survival of Salmonella enteritidis in transfected L cells, possibly by impaired nitric oxide production.
TL;DR: The inverse correlation between intracellular survival of Salmonella and the amount of nitrite detected in culture supernatants supports the hypothesis that the L-arginine-dependent NO pathway plays an important role in the murine fibroblast response against Salmoneella.
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Induction of alternative splicing of HLA-B27 by bacterial invasion.
Feng Huang,Akihiro Yamaguchi,Naoyuki Tsuchiya,Takashi Ikawa,Naoto Tamura,Mika Virtala,Kaisa Granfors,Parvin M. Yasaei,David T. Y. Yu,David T. Y. Yu +9 more
TL;DR: The association between arthritis-causing bacteria and HLA-B27 positive cells is a complex event and Soluble HLA -B27 is a potential key player.
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Human monocytic U937 cells kill Salmonella in vitro by NO-independent mechanisms
TL;DR: Both human monocytic transfectants produced NO equally well and killed Salmonella via NO-independent mechanisms and this study studied whether impaired elimination of Salmoneella would result from differences in NO production between HLA-B27- and Hla-A2-transfected U937 cells.
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