Mihoko Kamiyama
Johns Hopkins University
7 Papers
93 Citations
Mihoko Kamiyama is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cancer & Pancreatic cancer. The author has an hindex of 7, co-authored 7 publications.
Chat about Author
Papers
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Siân Jones,Xiaosong Zhang,D. Williams Parsons,D. Williams Parsons,Jimmy Lin,Rebecca J. Leary,Philipp Angenendt,Parminder Mankoo,Hannah Carter,Hirohiko Kamiyama,Antonio Jimeno,Seung-Mo Hong,Baojin Fu,Ming Tseh Lin,Eric S. Calhoun,Mihoko Kamiyama,Kimberly Walter,Tatiana Nikolskaya,Yuri Nikolsky,James Hartigan,Douglas Smith,Manuel Hidalgo,Steven D. Leach,Alison P. Klein,Elizabeth M. Jaffee,Michael Goggins,Anirban Maitra,Anirban Maitra,Christine A. Iacobuzio-Donahue,James R. Eshleman,Scott E. Kern,Ralph H. Hruban,Rachel Karchin,Nickolas Papadopoulos,Giovanni Parmigiani,Bert Vogelstein,Victor E. Velculescu,Kenneth W. Kinzler +37 more
TL;DR: It is found that pancreatic cancers contain an average of 63 genetic alterations, the majority of which are point mutations, which defined a core set of 12 cellular signaling pathways and processes that were each genetically altered in 67 to 100% of the tumors.
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
Shinichi Yachida,Siân Jones,Ivana Bozic,Tibor Antal,Tibor Antal,Rebecca J. Leary,Baojin Fu,Mihoko Kamiyama,Ralph H. Hruban,James R. Eshleman,Martin A. Nowak,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein,Christine A. Iacobuzio-Donahue +14 more
TL;DR: In this article, the authors rely on data generated by sequencing the genomes of seven pancreatic cancer metastases to evaluate the clonal relationships among primary and metastatic cancers and find that clonal populations that give rise to distant metastases are represented within the primary carcinoma, but these clones are genetically evolved from the original parental, non-metastatic clone.
Absence of germline BRCA1 mutations in familial pancreatic cancer patients.
Jennifer E. Axilbund,Pedram Argani,Mihoko Kamiyama,Emily Palmisano,Marian Raben,Michael Borges,Kieran Brune,Michael Goggins,Ralph H. Hruban,Alison P. Klein +9 more
TL;DR: The findings suggest that mutations in the BRCA1 gene are not highly, or even moderately, prevalent in families with a clustering of pancreatic cancer, including Pancreas Tumor Registry patients who report a family history of breast and/or ovarian cancer.
56
Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice
Hirohiko Kamiyama,Sherri Rauenzahn,Joong Sup Shim,Collins Karikari,Georg Feldmann,Li Hua,Mihoko Kamiyama,F. William Schuler,Ming Tseh Lin,Robert Beaty,Balasubramanyam Karanam,Hong Liang,Michael Mullendore,Guanglan Mo,Manuel Hidalgo,Elizabeth M. Jaffee,Ralph H. Hruban,H. A. Jinnah,Richard B.S. Roden,Antonio Jimeno,Jun O. Liu,Anirban Maitra,James R. Eshleman +22 more
TL;DR: Chemotherapy can be personalized using patient-specific cell lines derived in biochemically selectable mice, as shown by high-throughput chemosensitivity testing of low-passage cancer cell lines from primary cancers.
32
In vivo and in vitro propagation of intraductal papillary mucinous neoplasms.
Hirohiko Kamiyama,Mihoko Kamiyama,Seung-Mo Hong,Collins Karikari,Ming Tseh Lin,Michael Borges,Margaret Griffith,Angela Young,Alexis Norris-Kirby,Conrad Lubek,Masamichi Mizuma,Georg Feldmann,Chanjuan Shi,Hong Liang,Michael Goggins,Anirban Maitra,Ralph H. Hruban,James R. Eshleman +17 more
TL;DR: In vivo and in vitro growth of selected IPMNs were attempted based on the hypothesis that IPMNs could be grown in the most severely immunodeficient mice, and one IPMNs, with an associated invasive carcinoma, was successfully established as a cell line.
18