Mihály Herczeg
University of Debrecen
61 Papers
297 Citations
Mihály Herczeg is an academic researcher from University of Debrecen. The author has contributed to research in topics: Chemistry & Acetal. The author has an hindex of 12, co-authored 50 publications. Previous affiliations of Mihály Herczeg include Hungarian Academy of Sciences.
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Papers
Synthesis of S-linked glycoconjugates and S-disaccharides by thiol-ene coupling reaction of enoses.
TL;DR: Free-radical hydrothiolation of the endocyclic double bond of enoses is reported and Reaction between 2-acetoxy-D-glucal and a range of thiols including amino acid, peptide, glycosylThiols, and sugars with primary or secondary thiol functions gave S-linked α- glucoconjugates and S-disaccharides with full regio- and stereoselectivity.
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Systematic study on free radical hydrothiolation of unsaturated monosaccharide derivatives with exo- and endocyclic double bonds
László Lázár,Magdolna Csávás,Ádám Hadházi,Mihály Herczeg,Marietta Tóth,László Somsák,Terézia Barna,Pál Herczegh,Anikó Borbás +8 more
TL;DR: It is demonstrated that the endocyclic double bond of Neu5Ac-2-ene, bearing an electron-withdrawing substituent, shows sufficient reactivity in the photoinduced thiol-ene coupling reaction.
Synthesis and anticoagulant activity of bioisosteric sulfonic-Acid analogues of the antithrombin-binding pentasaccharide domain of heparin.
Mihály Herczeg,László Lázár,Zsuzsanna Bereczky,Katalin E. Kövér,István Timári,János Kappelmayer,András Lipták,Sándor Antus,Anikó Borbás +8 more
TL;DR: In vitro evaluation of the anticoagulant activity of these new sulfonic-acid derivatives revealed that the disulfonate analogue inhibited the blood-coagulation-proteinase factor Xa with outstanding efficacy; however, the introduction of the third sulfonate moiety resulted in a notable decrease in the anti-Xa activity.
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Tricyclanos: conformationally constrained nucleoside analogues with a new heterotricycle obtained from a D-ribofuranose unit
Máté Kicsák,Attila Mándi,Szabolcs Varga,Mihály Herczeg,Gyula Batta,Attila Bényei,Anikó Borbás,Pál Herczegh +7 more
TL;DR: A novel type of nucleoside analogue in which the sugar part is replaced by a new tricycle, 3,7,10-trioxa-11-azatricyclo has been prepared by substrate-controlled asymmetric synthesis by aiding conventional NMR experiments followed by chemical shift calculations using an X-ray crystal structure as reference.
Systematic Study on Free Radical Hydrothiolation of Unsaturated Monosaccharide Derivatives with Exo- and Endocyclic Double Bonds.
László Lázár,Magdolna Csávás,Ádám Hadházi,Mihály Herczeg,Marietta Tóth,László Somsák,Terézia Barna,Pál Herczegh,Anikó Borbás +8 more
TL;DR: The photo-induced radical-mediated hydrothiolation reactions show highly varying overall conversions depending not only on the substitution pattern and electron density of the double bond but also on the nature and substitution pattern of the thiol partner as mentioned in this paper.
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