Miguel A. Pappolla
University of Texas Medical Branch
128 Papers
1.4K Citations
Miguel A. Pappolla is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Oxidative stress & Medicine. The author has an hindex of 46, co-authored 121 publications. Previous affiliations of Miguel A. Pappolla include United States Department of Veterans Affairs & University of Lübeck.
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Papers
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.
Lorenzo M. Refolo,Miguel A. Pappolla,Brian Malester,John LaFrancois,Tara Bryant-Thomas,Rong Wang,G. Stephen Tint,Kumar Sambamurti,Karen Duff +8 more
TL;DR: It is proposed that diet can be used to modulate the risk of developing AD and high dietary cholesterol increases Aβ accumulation and accelerates the AD-related pathology observed in this animal model.
1K
RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer's Disease
Akihiko Nunomura,George Perry,Miguel A. Pappolla,Ramon Wade,Keisuke Hirai,Shigeru Chiba,Mark A. Smith,Mark A. Smith +7 more
TL;DR: Surprisingly, the oxidized nucleoside was associated predominantly with RNA because immunoreaction was diminished greatly by preincubation in RNase but only slightly by DNase, the first evidence of increased RNA oxidation restricted to vulnerable neurons in AD.
769
Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress
Mark A. Smith,Keisuke Hirai,Karen Hsiao,Miguel A. Pappolla,Peggy L.R. Harris,Sandra L. Siedlak,Massimo Tabaton,George Perry +7 more
TL;DR: Evidence that amyloid‐β and oxidative damage are inextricably linked in vivo is provided, and the use of transgenic animals for the development of antioxidant therapeutic strategies is supported.
577
Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid *
Yau Jan Chyan,Burkhard Poeggeler,Rawhi A. Omar,Daniel G. Chain,Blas Frangione,Jorge Ghiso,Miguel A. Pappolla +6 more
TL;DR: In kinetic competition experiments using free radical-trapping agents, the capacity of IPA to scavenge hydroxyl radicals exceeded that of melatonin, an indoleamine considered to be the most potent naturally occurring scavenger of free radicals.
389
•Journal Article
Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.
TL;DR: The hypothesis that oxidative stress may be involved in the pathogenesis of Alzheimer's disease is supported.
378