Miguel A. Andrade-Navarro

TL;DR: O4I2 and its derivatives should provide a new class of small molecules suitable for iPSC generation, based on a cell-based high throughput screening campaign identified several potential small molecules as inducers of Oct3/4 expression.

TL;DR: It is found that the MC3 compound activates TGFβ signalling while reducing Il-2 expression and CD4+ T-cell activation and suppresses autoimmune phenotypes in a mouse model of IPEX syndrome, suggesting that the immunosuppressive activity of gold compounds can be improved by introducing planar NHC ligands to activate the AHR-associated immunOSuppressive pathway, thus expanding their potential clinical application for autoimmune diseases.

TL;DR: A new algorithm for subcellular location prediction that uses residue exposure signatures and a novel approach to address the multiclass classification problem is developed.

TL;DR: It is revealed that RBULs engage in stable interactions with RNA-binding proteins involved in different steps of RNA metabolism as well as with components of the ubiquitin conjugation machinery and Ubiquitin- binding proteins.