Michihiro Mitobe
Yale University
6 Papers
Michihiro Mitobe is an academic researcher from Yale University. The author has contributed to research in topics: PKD1 & Polycystic kidney disease. The author has an hindex of 4, co-authored 6 publications.
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Papers
Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1
Sekiya Shibazaki,Zhiheng Yu,Saori Nishio,Xin Tian,R. Brent Thomson,Michihiro Mitobe,Angeliki Louvi,Heino Velazquez,Shuta Ishibe,Lloyd G. Cantley,Peter Igarashi,Stefan Somlo +11 more
TL;DR: Cysts in ADPKD exhibit both increased proliferation and activation of MAPK/ERK, but cyst growth is not prevented by inhibition of ERK1/2 activation.
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A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation
Sorin V. Fedeles,Xin Tian,Anna Rachel Gallagher,Michihiro Mitobe,Saori Nishio,Seung Hun Lee,Yiqiang Cai,Lin Geng,Craig M. Crews,Stefan Somlo +9 more
TL;DR: It is shown that proteasome inhibition increases steady-state levels of polycystin-1 in cells lacking glucosidase IIβ and that treatment with a proteasomesome inhibitor reduces cystic disease in orthologous gene models of human autosomal dominant polycystic liver disease.
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Altered trafficking and stability of polycystins underlie polycystic kidney disease
Yiqiang Cai,Sorin V. Fedeles,Ke Dong,Georgia I. Anyatonwu,Tamehito Onoe,Michihiro Mitobe,Jian-Dong Gao,Dayne Okuhara,Xin Tian,Anna Rachel Gallagher,Zhangui Tang,Xiaoli Xie,Maria D. Lalioti,Ann-Hwee Lee,Barbara E. Ehrlich,Stefan Somlo +15 more
TL;DR: It is demonstrated that PC1 trafficking and expression require GPS cleavage and PC2 interaction, respectively, and a framework for functional assays to categorize the effects of missense mutations in polycystins is provided.
Biliary and Pancreatic Dysgenesis in Mice Harboring a Mutation in Pkhd1
Anna Rachel Gallagher,Ernie L. Esquivel,Tiffany S. Briere,Xin Tian,Michihiro Mitobe,Luis F. Menezes,Glen S. Markowitz,Dhanpat Jain,Luiz F. Onuchic,Stefan Somlo +9 more
TL;DR: The hypomorphic Pkhd1(del4/del4) mouse model provides evidence that reduced functional levels of fibrocystin are sufficient for cystogenesis and fibrosis in the liver and pancreas, but not the kidney, and supports the hypothesis of species-dependent differences in susceptibility of tissues to PkhD1 mutations.
Significance of kidney biopsy in autosomal dominant tubulointerstitial kidney disease-UMOD: is kidney biopsy truly nonspecific?
Tamehito Onoe,Satoshi Hara,Kazunori Yamada,Takeshi Zoshima,Ichiro Mizushima,Kiyoaki Ito,Takayasu Mori,Shoichiro Daimon,Hiroaki Muramoto,Maki Shimizu,Akira Iguchi,Akihiro Kuma,Yoshifumi Ubara,Michihiro Mitobe,Hiroaki Tsuruta,Nao Kishimoto,Junko Imura,Tadashi Konoshita,Mitsuhiro Kawano +18 more
TL;DR: In this article, the significance of kidney biopsy in Autosomal dominant tubulointerstitial kidney disease (ADTKD)-UMOD patients was evaluated, and the results indicated that kidney biopsies may provide important clues to the diagnosis of the disease.