Michelle Wragg
Washington University in St. Louis
9 Papers
Michelle Wragg is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Presenilin & Allele. The author has an hindex of 9, co-authored 9 publications.
Chat about Author
Papers
The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families
Robert Clark,Mike Hutton,Rebecca A. Fuldner,Sue Froelich,Eric Karran,Christopher Talbot,Richard Crook,Corinne Lendon,Guy Prihar,C He,Kevin M. Korenblat,Alonso Martínez,Alonso Martínez,Michelle Wragg,F. Busfield,Maria I. Behrens,Amanda J. Myers,Joanne Norton,John C. Morris,N Mehta,Chad G. Pearson,Sarah Lincoln,M Baker,Karen Duff,C Zehr,Jordi Pérez-Tur,Harry Houlden,Adriana Ruiz,Jorge Ossa,Francisco Lopera,M. Arcos,Lucia Madrigal,John Collinge,C Humphreys,T Ashworth,S Sarner,Nick C. Fox,R Harvey,A Kennedy,P Roques,Cline Rt,Phillips Ca,Venter Jc,Lotta Forsell,Karin Axelman,Lena Lilius,Janet A. Johnston,R Cowburn,Matti Viitanen,Bengt Winblad,Ken Kosik,Matti Haltia,Minna Pöyhönen,Dennis W. Dickson,David G. Mann,D Neary,Julie S. Snowden,Peter L. Lantos,Lars Lannfelt,Martin N. Rossor,George Roberts,Mark Raymond Adams,John Hardy,Alison Goate +63 more
TL;DR: This work has localized the PS-1 gene to a 75 kb region and present the structure of this gene, evidence for alternative splicing and describe six novel mutations in early onset FAD pedigrees all of which alter residues conserved in the STM26 (Presenilin 2: PS-2) gene.
496
A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene.
Jordi Pérez-Tur,S Froelich,G. Prihar,Richard Crook,Matt Baker,Karen Duff,Michelle Wragg,F. Busfield,Corinne Lendon,Robert Clark +9 more
TL;DR: The intron/exon structure of the PS-1 gene has been determined and this information has been used to identify a mutation in the splice acceptor site for exon 9 in a family with early onset Alzheimer's disease.
280
Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease
Mike Hutton,F. Busfield,Michelle Wragg,Richard Crook,Jordi Pérez-Tur,Robert Clark,G. Prihar,C. Conover Talbot,Phillips H,Kristal Wright,Matt Baker,C. Lendon,Karen Duff,Alonso Martínez,H. Houlden,Nichols A,Eric Karran,G.W. Roberts,P Roques,Martin N. Rossor,Venter Jc,Adams,Cline Rt,Phillips Ca,Alison Goate +24 more
TL;DR: The intron/exon structure of the gene is elucidated and intronic primers are designed to enable direct sequencing of the entire coding region (10 exons) of the presenilin gene in a large number of families.
168
E280A PS-1 mutation causes Alzheimer's disease but age of onset is not modified by ApoE alleles
Corinne Lendon,Alonso Martínez,Alonso Martínez,Isabel Maria Behrens,Kenneth S. Kosik,Lucia Madrigal,Joanne Norton,Rosalind J. Neuman,Amanda J. Myers,Frances Busfield,Michelle Wragg,M. Arcos,Juan Carlos Arango Viana,Jorge Ossa,Andrés Ruiz,Alison Goate,Francisco Lopera +16 more
TL;DR: The presence of a single mutation and the common geographic origin, with all families from the state of Antioquia, suggest a founder effect in this population of early‐onset Alzheimer's disease cases, supported by the observation of a rare haplotype inherited with AD in all kindreds.
94
The role of presenilin 1 in the genetics of Alzheimer's disease.
Robert Clark,Mike Hutton,Christopher Talbot,Michelle Wragg,Corinne Lendon,F. Busfield,Steve S.W. Han,Jordi Pérez-Tur,Mark Raymond Adams,Rebecca A. Fuldner,George Roberts,Eric Karran,John Hardy,Alison Goate +13 more
TL;DR: Identification of all susceptibility loci for AD is a major goal in resolving the pathogenesis of AD and the work on ApoE indicates that the epsilon 4 allele is a risk factor for developing AD.
14