Michelle Vaz
Johns Hopkins University
24 Papers
85 Citations
Michelle Vaz is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 12, co-authored 20 publications. Previous affiliations of Michelle Vaz include University of Illinois at Chicago & Johns Hopkins University School of Medicine.
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Papers
Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer
Michael J. Topper,Michael J. Topper,Michelle Vaz,Katherine B. Chiappinelli,Christina E. DeStefano Shields,Noushin Niknafs,Ray Whay Chiu Yen,Alyssa Wenzel,Jessica Hicks,Matthew Ballew,Meredith L. Stone,Meredith L. Stone,Phuoc T. Tran,Cynthia A. Zahnow,Matthew D. Hellmann,Valsamo Anagnostou,Pamela L. Strissel,Reiner Strick,Victor E. Velculescu,Stephen B. Baylin +19 more
TL;DR: Using in-vitro-treated NSCLC cell lines, it is elucidate an interferon α/β-based transcriptional program with accompanying upregulation of antigen presentation machinery, mediated in part through double-stranded RNA (dsRNA) induction, which reverses tumor immune evasion and modulates T cell exhaustion state towards memory and effector T-cell phenotypes.
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The emerging role of epigenetic therapeutics in immuno-oncology.
TL;DR: The basic dynamic mechanisms underlying the synergy between immunotherapy and epigenetic therapies are highlighted and current efforts to translate this knowledge into clinical benefit for patients are detailed.
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Epigenetic therapy inhibits metastases by disrupting premetastatic niches
Zhihao Lu,Zhihao Lu,Zhihao Lu,Jianling Zou,Shuang Li,Michael J. Topper,Yong Tao,Hao Zhang,Xi Jiao,Wenbing Xie,Xiangqian Kong,Michelle Vaz,Huili Li,Yi Cai,Limin Xia,Limin Xia,Peng Huang,Kristen Rodgers,Beverly Lee,Joanne Riemer,Chi-Ping Day,Ray Whay Chiu Yen,Ying Cui,Yujiao Wang,Yanni Wang,Weiqiang Zhang,Weiqiang Zhang,Hariharan Easwaran,Alicia Hulbert,Alicia Hulbert,Ki Bem Kim,Rosalyn A. Juergens,Stephen C. Yang,Richard J. Battafarano,Errol L. Bush,Stephen R. Broderick,Stephen M. Cattaneo,Julie R. Brahmer,Charles M. Rudin,John Wrangle,Yuping Mei,Yuping Mei,Young J. Kim,Bin Zhang,Bin Zhang,Ken Kang Hsin Wang,Patrick M. Forde,Patrick M. Forde,Joseph B. Margolick,Barry D. Nelkin,Cynthia A. Zahnow,Drew M. Pardoll,Drew M. Pardoll,Franck Housseau,Franck Housseau,Stephen B. Baylin,Lin Shen,Malcolm V. Brock,Malcolm V. Brock +58 more
TL;DR: It is shown that, after surgical removal of primary lung, breast and oesophageal cancers, low-dose adjuvant epigenetic therapy disrupts the premetastatic microenvironment and inhibits both the formation and growth of lung metastases through its selective effect on myeloid-derived suppressor cells (MDSCs).
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Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations
Michelle Vaz,Stephen Y. Hwang,Ioannis Kagiampakis,Jillian Phallen,Ashwini Patil,Heather M. O'Hagan,Lauren Murphy,Cynthia A. Zahnow,Edward Gabrielson,Victor E. Velculescu,Hariharan Easwaran,Stephen B. Baylin +11 more
TL;DR: Chronic cigarette smoke-induced time-dependent epigenetic alterations can sensitize human bronchial epithelial cells for transformation by a single oncogene involved in lung cancer initiation, and these cells transform by introducing a single KRAS mutation and form adenosquamous lung carcinomas in mice.
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The Transcription Factor Encyclopedia
Dimas Yusuf,Stefanie L. Butland,Magdalena I. Swanson,Eugene Bolotin,Amy Ticoll,Warren A. Cheung,Xiao Yu Cindy Zhang,Christopher Td Dickman,Debra L. Fulton,Jonathan Lim,Jake Schnabl,Oscar H. P. Ramos,Mireille Vasseur-Cognet,Charles N. de Leeuw,Elizabeth M. Simpson,Gerhart U. Ryffel,Eric Lam,Ralf Kist,Miranda Sc Wilson,Raquel Marco-Ferreres,Jan J. Brosens,Leonardo Beccari,Paola Bovolenta,Bérénice A. Benayoun,Lara J. Monteiro,Helma Dc Schwenen,Lars Grøntved,Elizabeth D. Wederell,Susanne Mandrup,Reiner A. Veitia,Harini Chakravarthy,Pamela A. Hoodless,M. Michela Mancarelli,Bruce E. Torbett,Alison H. Banham,Sekhar P. Reddy,Rebecca L. Cullum,Michaela Liedtke,Mario P. Tschan,Michelle Vaz,Angie Rizzino,Mariastella Zannini,Seth Frietze,Peggy J. Farnham,Astrid Eijkelenboom,Philip J. Brown,David Laperrière,Dominique Leprince,Tiziana de Cristofaro,Kelly L. Prince,Marrit Putker,Luis del Peso,Gieri Camenisch,Roland H. Wenger,Michal Mikula,Marieke Rozendaal,Sylvie Mader,Jerzy Ostrowski,Simon J. Rhodes,Capucine Van Rechem,Gaylor Boulay,Sam W. Z. Olechnowicz,Mary B. Breslin,Michael S. Lan,Kyster K. Nanan,Michael Wegner,Juan Hou,Rachel D. Mullen,Stephanie C. Colvin,Peter J. Noy,Carol F. Webb,Matthew E. Witek,Scott Ferrell,Juliet M. Daniel,Jason Y. Park,Scott A. Waldman,Daniel J. Peet,Michael J. Taggart,Padma-Sheela Jayaraman,Julien J. Karrich,Bianca Blom,Farhad Vesuna,Henriette O'Geen,Yunfu Sun,Richard M. Gronostajski,Mark W. Woodcroft,Margaret R. Hough,Edwin Chen,Nicholas Europe-Finner,Magdalena Karolczak-Bayatti,Jarrod Bailey,Oliver Hankinson,Venu Raman,David P. LeBrun,Shyam Biswal,Christopher J. Harvey,Jason P. DeBruyne,John B. Hogenesch,Robert F. Hevner,Christophe Héligon,Xin M. Luo,Marissa Cathleen Blank,Kathleen J. Millen,David S. Sharlin,Douglas Forrest,Karin Dahlman-Wright,Chunyan Zhao,Yuriko Mishima,Satrajit Sinha,Rumela Chakrabarti,Elodie Portales-Casamar,Frances M. Sladek,Philip Bradley,Wyeth W. Wasserman +113 more
TL;DR: The Transcription Factor Encyclopedia (TFe), a new web-based compendium of mini review articles on transcription factors (TFs) that is founded on the principles of open access and collaboration, is presented.
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