Michelle Solomon
Arena Pharmaceuticals, Inc.
7 Papers
34 Citations
Michelle Solomon is an academic researcher from Arena Pharmaceuticals, Inc.. The author has contributed to research in topics: Receptor & Chemistry. The author has an hindex of 6, co-authored 7 publications.
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Papers
Embelin and its derivatives unravel the signaling, proinflammatory and antiatherogenic properties of GPR84 receptor.
Ibragim Gaidarov,Todd Anthony,Joel Gatlin,Xiaohua Chen,David Mills,Michelle Solomon,Sangdon Han,Graeme Semple,David J. Unett +8 more
TL;DR: The data suggest that GPR84 may be a target of therapeutic value and that distinct modes of receptor modulation (inhibition vs. stimulation) may be required for inflammatory and atherosclerotic indications.
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Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain
Sangdon Han,Lars Thoresen,Jae-Kyu Jung,Xiuwen Zhu,Jayant Thatte,Michelle Solomon,Ibragim Gaidarov,David J. Unett,Woo Hyun Yoon,Jeremy Barden,Abu J.M. Sadeque,Amin Usmani,Chuan Chen,Graeme Semple,Andrew J. Grottick,Hussien A. Al-Shamma,Christopher Ronald J,Robert M. Jones +17 more
TL;DR: Compound 6 was efficacious in a rat model of osteoarthritis pain following oral administration and maintained its analgesic effect throughout a 5-day subchronic treatment paradigm, consistent with the hypothesis that full agonist efficacy is required for efficient internalization and recycling of the CB2 receptor to avoid tachyphylaxis.
Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease
Daniel J. Buzard,Sangdon Han,Luis Lopez,Andrew M. Kawasaki,Moody Jeanne,Lars Thoresen,Brett Ullman,Juerg Lehmann,Imelda Calderon,Xiuwen Zhu,Tawfik Gharbaoui,Dipanjan Sengupta,Krishnan Ashwin M,Yinghong Gao,Jeff Edwards,Jeremy Barden,Michael Morgan,Khawja A. Usmani,Chuan Chen,Abu J.M. Sadeque,Jayant Thatte,Michelle Solomon,Lixia Fu,Kevin Whelan,Ling Liu,Hussien A. Al-Shamma,Joel Gatlin,Minh Le,Charles Xing,Sheryll Espinola,Robert M. Jones +30 more
TL;DR: Two series of fused tricyclic indoles were identified as potent and selective S1P(1) agonists which produced a significant reduction in circulating lymphocytes which translated into robust efficacy in several rodent models of autoimmune disease.
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(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists
Daniel J. Buzard,Luis Lopez,Moody Jeanne,Andrew M. Kawasaki,Thomas O. Schrader,Michelle Kasem,Ben Johnson,Xiuwen Zhu,Lars Thoresen,Sun Hee Kim,Tawfik Gharbaoui,Dipanjan Sengupta,Lorene Calvano,Krishnan Ashwin M,Yinghong Gao,Graeme Semple,Jeff Edwards,Jeremy Barden,Michael Morgan,Khawja A. Usmani,Chuan Chen,Abu J.M. Sadeque,Weichao Chen,Christopher Ronald J,Jayant Thatte,Lixia Fu,Michelle Solomon,Kevin Whelan,Hussien A. Al-Shamma,Joel Gatlin,Ibragim Gaidarov,Todd Anthony,Minh Le,David J. Unett,Scott Stirn,Anthony C. Blackburn,Dominic P. Behan,Robert M. Jones +37 more
TL;DR: The discovery and optimization of (7-benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acids as potent, centrally available, direct acting S1P1 functional antagonists, with favorable pharmacokinetic and safety properties are described.
Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P1 agonists
Daniel J. Buzard,Sangdon Han,Lars Thoresen,Moody Jeanne,Luis Lopez,Andrew M. Kawasaki,Thomas O. Schrader,Carleton R. Sage,Yinghong Gao,Jeff Edwards,Jeremy Barden,Jayant Thatte,Lixia Fu,Michelle Solomon,Ling Liu,Hussien A. Al-Shamma,Joel Gatlin,Minh Le,Charles Xing,Sheryll Espinola,Robert M. Jones +20 more
TL;DR: A novel chemical series of 4-oxo-4-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl (butanoic acid) S1P(1) receptor agonists is identified for lymphopenia and it is shown that this series has the potential to treat an array of autoimmune disease states.
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