Michelle E. Maxson
Hospital for Sick Children
17 Papers
21 Citations
Michelle E. Maxson is an academic researcher from Hospital for Sick Children. The author has contributed to research in topics: Phagosome & Macropinosome. The author has an hindex of 5, co-authored 10 publications.
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Papers
The vacuolar-type H+-ATPase at a glance – more than a proton pump
TL;DR: These non-canonical functions of the V-ATPase, which include fusogenicity, cytoskeletal tethering and metabolic sensing, are described in this Cell Science at a Glance article and accompanying poster.
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Constitutive and stimulated macropinocytosis in macrophages: roles in immunity and in the pathogenesis of atherosclerosis.
TL;DR: The role of macropinocytosis in the uptake of modified low-density lipoprotein (LDL) and its contribution to foam cell and atherosclerotic plaque formation is analysed and a combined role of scavenger receptors and constitutive macrop in oxidized LDL uptake is proposed.
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Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation
Nicole M. Revie,Kali R. Iyer,Michelle E. Maxson,Jiabao Zhang,Sun Yan,Caroline Mota Fernandes,Kirsten J. Meyer,Xuefei Chen,Iwona Skulska,Meea Fogal,Hiram Sanchez,Saif Hossain,Sheena C. Li,Yoko Yashiroda,Hiroyuki Hirano,Minoru Yoshida,Hiroyuki Osada,Charles Boone,Rebecca S. Shapiro,David R. Andes,Gerard D. Wright,Justin R. Nodwell,Maurizio Del Poeta,Martin D Burke,Luke Whitesell,Nicole Robbins,Leah E. Cowen +26 more
TL;DR: In this paper , the authors used a combinatorial screening approach to identify an imidazopyrazoindole, NPD827, that synergizes with fluconazole against azole-sensitive and -resistant isolates of Candida albicans.
Rab5 regulates macropinocytosis by recruiting the inositol 5-phosphatases OCRL and Inpp5b that hydrolyse PtdIns(4,5)P2.
Michelle E. Maxson,Helen Sarantis,Allen Volchuk,John H. Brumell,Sergio Grinstein,Sergio Grinstein +5 more
TL;DR: This paper showed that Rab5-containing vesicles were recruited to circular membrane ruffles, and soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent endomembrane fusion was necessary for the completion of macropinocytosis.
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Respiration supports intraphagosomal filamentation and escape of Candida albicans from macrophages
Nicola T. Case,Johannes Westman,Michael T Hallett,Jonathan Plumb,Aiman Farheen,Michelle E. Maxson,Jessie MacAlpine,Sean D Liston,Bernhard Hube,Nicole Robbins,Luke Whitesell,S. Grinstein,Leah E. Cowen +12 more
TL;DR: Functional genomic screening of conditional-expression mutants covering >50% of the C. albicans genome was employed to identify genes selectively required for filamentation inside macrophages and uncovered a role for the mitochondrial ribosome, respiration, and the SNF1 AMP-activated kinase complex in governing filamentous growth within the phagosome.
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