Michelle A. Guney
Vanderbilt University Medical Center
6 Papers
Michelle A. Guney is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Pancreas & CTGF. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Michelle A. Guney include Vanderbilt University.
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Papers
A physiological role for connective tissue growth factor in early wound healing
Maria P. Alfaro,Desirae L. Deskins,Meredith Wallus,Jayasri DasGupta,Jeffrey M. Davidson,Jeffrey M. Davidson,Lillian B. Nanney,Michelle A. Guney,Maureen Gannon,Pampee P. Young,Pampee P. Young +10 more
TL;DR: It is demonstrated that when CTGF expression is confined to early tissue repair, it serves a pro-reparative role and the potential of MSC-derived paracrine modulators to enhance tissue repair.
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Connective tissue growth factor acts within both endothelial cells and β cells to promote proliferation of developing β cells
Michelle A. Guney,Christine P. Petersen,Andre Boustani,Matthew R. Duncan,Uma Gunasekaran,Renuka Menon,Courtney Warfield,Gary R. Grotendorst,Anna L. Means,Aris N. Economides,Maureen Gannon +10 more
TL;DR: It is demonstrated that CTGF acts in an autocrine manner during pancreas development and suggested thatCTGF has the potential to enhance expansion of immature β cells in directed differentiation or regeneration protocols.
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Pancreas Cell Fate
Michelle A. Guney,Maureen Gannon +1 more
TL;DR: This review summarizes the current understanding of pancreas development, with particular emphasis on factors intrinsic or extrinsic to the pancreatic epithelium that are involved in regulating the development and differentiation of the various pancreatic cell types.
OASIS/CREB3L1 Induces Expression of Genes Involved in Extracellular Matrix Production But Not Classical Endoplasmic Reticulum Stress Response Genes in Pancreatic β-Cells
Ravi N. Vellanki,Liling Zhang,Michelle A. Guney,Jonathan V. Rocheleau,Jonathan V. Rocheleau,Maureen Gannon,Allen Volchuk,Allen Volchuk +7 more
TL;DR: The results suggest that the repertoire of genes induced by OASIS is cell type-dependent and that the OasIS protein may have a role in pancreas development.
Major β cell-specific functions of NKX2.2 are mediated via the NK2-specific domain.
Joshua A. Levine,Angela J. Churchill,Cailin Deiter,Michelle A. Guney,Kristen L. Wells,Jessica M. Schrunk,Yuchun Guo,Jennifer Hammelman,David K. Gifford,Mark A. Magnuson,Hynek Wichterle,Lori Sussel +11 more
TL;DR: In this paper , the authors demonstrate that β cell-specific functions of NKX2.2 are driven by the highly conserved NK2-specific domain (SD) and demonstrate that deletion of the SD prevents the developmental progression of β cell precursors into mature, insulin-expressing β cells, resulting in overt neonatal diabetes.